Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 5/20 | 0.33 |
| ▸ | PIK3R2 | O00459 | 5/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.33 |
| ▸ | PIK3R5 | Q8WYR1 | 5/20 | 0.33 |
| ▸ | PIK3R3 | Q92569 | 5/20 | 0.33 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.31 |
| ▸ | CDK2 | P24941 | 2/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9175362 | 0.89 | ALDH1A1 (0.41) | MAPTNPSR1ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL9173767 | 0.88 | PIK3CD (0.35) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL9316676 | 0.88 | PIK3CD (0.32) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL9173537 | 0.86 | KDR (0.35) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL9167925 | 0.86 | NPC1 (0.33) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL9173354 | 0.85 | PIK3CD (0.42) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL9171740 | 0.85 | PIK3CD (0.39) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL9175534 | 0.84 | NTRK1 (0.34) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL9172719 | 0.84 | KIT (0.37) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL9175325 | 0.83 | IDO1 (0.38) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0434807-B1 | HETEROARYL-3-OXO-PROPANENITRILE DERIVATIVES USEFUL IN STIMULATING MYELOPOIESIS | ERBA CARLO SPA (IT) | 1994-06-08 | — | — | EP | claimed |
| EP-0423269-B1 | HETEROARYL-3-OXO-PROPANENITRILE DERIVATIVES USEFUL IN THE TREATMENT OF RHEUMATOID ARTHRITIS AND OTHER AUTOIMMUNE DISEASES | ERBA CARLO SPA (IT) | 1994-01-12 | — | — | EP | claimed |
| WO-1991001309-A1 | HETEROARYL-3-OXO-PROPANENITRILE DERIVATIVES USEFUL IN STIMULATING MYELOPOIESIS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1991-02-07 | — | — | WO | claimed |
| US-5424308-A | Immunomodulating agents | FARMITALIA CARLO ERBA S.R.L. (IT) | 1995-06-13 | — | — | US | disclosed |
| US-5352676-A | Morphalinomethyl-substituted 1-phenyl-indero-[1,2-c]pyrazol-3-yl derivatives of 2-cyano-3-oxo-propanamides useful in the treatment of rheumatoid arthritis | FARMITALIA CARLO ERBA SRL (IT) | 1994-10-04 | — | — | US | disclosed |
| EP-0434807-B1 | HETEROARYL-3-OXO-PROPANENITRILE DERIVATIVES USEFUL IN STIMULATING MYELOPOIESIS | ERBA CARLO SPA (IT) | 1994-06-08 | — | — | EP | disclosed |
| EP-0423269-B1 | HETEROARYL-3-OXO-PROPANENITRILE DERIVATIVES USEFUL IN THE TREATMENT OF RHEUMATOID ARTHRITIS AND OTHER AUTOIMMUNE DISEASES | ERBA CARLO SPA (IT) | 1994-01-12 | — | — | EP | disclosed |
| US-5260328-A | Phenyl-indenopurazol 3-oxo-propanamide derivatives useful in the treatment of rheumatoid arthritis | FARMITALIA CARLO ERBA SRL (IT) | 1993-11-09 | — | — | US | disclosed |
| EP-0347773-B1 | CONDENSED PYRAZOLE 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1993-04-28 | — | — | EP | disclosed |
| US-5206258-A | Treating autoimmune disorders | FARMITALIA CARLO ERBA S.R.L. (IT) | 1993-04-27 | — | — | US | disclosed |
| US-5196445-A | HETEROARYL-3-OXO-PROPANENITRILE DERIVATIVES USEFUL IN THE TREATMENT OF RHEUMATOID ARTHRITIS AND OTHER AUTOIMMUNE DISEASES | FARMITALIA CARLO ERBA SRL (IT) | 1993-03-23 | — | — | US | disclosed |
| EP-0422051-A1 | CONDENSED PYRAZOLE 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1991-04-17 | — | — | EP | disclosed |
| WO-1991001309-A1 | HETEROARYL-3-OXO-PROPANENITRILE DERIVATIVES USEFUL IN STIMULATING MYELOPOIESIS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1991-02-07 | — | — | WO | disclosed |
| WO-1989012630-A1 | CONDENSED PYRAZOLE 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-12-28 | — | — | WO | disclosed |
| EP-0347773-A1 | Condensed Pyrazole 3-oxo-propanenitrile derivatives and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1989-12-27 | — | — | EP | disclosed |