Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.50 |
| ▸ | CCR2 | P41597 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 2/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | CHRNA1 | P02708 | 5/20 | 0.42 |
| ▸ | CHRNB1 | P11230 | 5/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.42 |
| ▸ | CHRNG | P07510 | 4/20 | 0.42 |
| ▸ | CHRND | Q07001 | 4/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23341010 | 0.96 | SLC6A3 (0.54) | SLC6A3SLC6A4SLC6A2CCR2DPP4 | |
| SCHEMBL6448660 | 0.94 | SLC6A4 (0.57) | SLC6A3SLC6A4SLC6A2CCR2DPP4 | |
| SCHEMBL9911479 | 0.92 | SLC6A3 (0.49) | SLC6A3SLC6A4SLC6A2CCR2DPP4 | |
| SCHEMBL22306040 | 0.76 | BACE1 (0.47) | SLC6A3SLC6A4SLC6A2OPRD1CHRNA1 | |
| SCHEMBL257282 | 0.76 | SLC6A4 (0.50) | SLC6A3SLC6A4SLC6A2CCR2OPRD1 | |
| SCHEMBL7349461 | 0.76 | SLC6A4 (0.54) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL28323043 | 0.76 | SLC6A3 (0.50) | SLC6A3SLC6A4SLC6A2CCR2OPRD1 | |
| SCHEMBL27906398 | 0.76 | SLC6A4 (0.50) | SLC6A3SLC6A4SLC6A2CCR2DPP4 | |
| SCHEMBL28804064 | 0.76 | SLC6A3 (0.46) | SLC6A3SLC6A4SLC6A2CCR2DPP4 | |
| Hydrochloric Acid SCHEMBL4493227 | 0.74 | SLC6A4 (0.53) | SLC6A3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0490772-B1 | 1,4-Disubstituted piperazines, their process of preparation and pharmaceutical compositions containing them | ADIR (FR) | 1995-07-26 | — | — | EP | disclosed |
| EP-0490772-A1 | 1,4-Disubstituted piperazines, their process of preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-06-17 | — | — | EP | disclosed |