Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9178221 | 1.00 | KDM4E (0.50) | KDM4ENPC1KMT2AMEN1CA1 | |
| SCHEMBL9175015 | 0.83 | NPC1 (0.43) | NPC1KMT2AMEN1CA1CA2 | |
| SCHEMBL9172002 | 0.78 | KDM4E (0.48) | KDM4ECA1CA2 | |
| SCHEMBL9174319 | 0.78 | KDM4E (0.48) | KDM4ECA1CA2 | |
| SCHEMBL12130771 | 0.77 | HTT (0.58) | KMT2AMEN1TSHRSMN1; SMN2 | |
| SCHEMBL13260005 | 0.77 | HTT (0.58) | KMT2AMEN1TSHRSMN1; SMN2 | |
| SCHEMBL30278915 | 0.77 | HTT (0.58) | KMT2AMEN1TSHRSMN1; SMN2 | |
| SCHEMBL10081735 | 0.77 | HTT (0.58) | KMT2AMEN1TSHRSMN1; SMN2 | |
| SCHEMBL9173225 | 0.74 | SMN1; SMN2 (0.51) | NPC1KMT2AMEN1TSHRSMN1; SMN2 | |
| SCHEMBL9177954 | 0.74 | SMN1; SMN2 (0.51) | NPC1KMT2AMEN1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0493346-B1 | Derivatives of 1,2,3,4-tetrahydronaphtylamine endowed with nootropic activity and pharmaceutical compositions containing same | SIGMA TAU IND FARMACEUTI (IT) | 1995-06-14 | — | — | EP | claimed |
| EP-0493346-A2 | Derivatives of 1,2,3,4-tetrahydronaphtylamine endowed with nootropic activity and pharmaceutical compositions containing same | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1992-07-01 | — | — | EP | claimed |
| EP-0493346-B1 | Derivatives of 1,2,3,4-tetrahydronaphtylamine endowed with nootropic activity and pharmaceutical compositions containing same | SIGMA TAU IND FARMACEUTI (IT) | 1995-06-14 | — | — | EP | disclosed |
| US-5192759-A | Cognition activators, learning enhancement | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1993-03-09 | — | — | US | disclosed |
| EP-0493346-A2 | Derivatives of 1,2,3,4-tetrahydronaphtylamine endowed with nootropic activity and pharmaceutical compositions containing same | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1992-07-01 | — | — | EP | disclosed |