Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | SCN4A | P35499 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 8/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 8/20 | 0.46 |
| ▸ | CA1 | P00915 | 4/20 | 0.42 |
| ▸ | CA2 | P00918 | 4/20 | 0.42 |
| ▸ | ACHE | P22303 | 3/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9174319 | 1.00 | KDM4E (0.48) | KDM4ESCN4AMTNR1AMTNR1BCA1 | |
| SCHEMBL9173853 | 0.81 | MTNR1A (0.46) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL9178221 | 0.78 | KDM4E (0.50) | KDM4ECA1CA2 | |
| SCHEMBL9178199 | 0.78 | KDM4E (0.50) | KDM4ECA1CA2 | |
| SCHEMBL10247041 | 0.76 | HDAC8 (0.55) | — | |
| SCHEMBL9175988 | 0.74 | MTNR1A (0.47) | KDM4ESCN4AMTNR1AMTNR1BCA1 | |
| SCHEMBL9175985 | 0.74 | MTNR1A (0.47) | KDM4ESCN4AMTNR1AMTNR1BCA1 | |
| SCHEMBL21798809 | 0.74 | MTNR1A (0.49) | KDM4EMTNR1AMTNR1BCA1CA2 | |
| SCHEMBL9781783 | 0.74 | CA1 (0.58) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL11040374 | 0.73 | MTNR1A (0.61) | MTNR1AMTNR1BCA1CA2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0493346-B1 | Derivatives of 1,2,3,4-tetrahydronaphtylamine endowed with nootropic activity and pharmaceutical compositions containing same | SIGMA TAU IND FARMACEUTI (IT) | 1995-06-14 | — | — | EP | claimed |
| EP-0493346-A2 | Derivatives of 1,2,3,4-tetrahydronaphtylamine endowed with nootropic activity and pharmaceutical compositions containing same | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1992-07-01 | — | — | EP | claimed |
| EP-0493346-B1 | Derivatives of 1,2,3,4-tetrahydronaphtylamine endowed with nootropic activity and pharmaceutical compositions containing same | SIGMA TAU IND FARMACEUTI (IT) | 1995-06-14 | — | — | EP | disclosed |
| US-5192759-A | Cognition activators, learning enhancement | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1993-03-09 | — | — | US | disclosed |
| EP-0493346-A2 | Derivatives of 1,2,3,4-tetrahydronaphtylamine endowed with nootropic activity and pharmaceutical compositions containing same | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1992-07-01 | — | — | EP | disclosed |