Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.53 |
| ▸ | HTR2C | P28335 | 3/20 | 0.53 |
| ▸ | CDK4 | P11802 | 4/20 | 0.49 |
| ▸ | CCND1 | P24385 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8121319 | 0.81 | HTR2C (0.55) | HTR2AHTR2CMAPTPRMT5HTR7 | |
| SCHEMBL8128124 | 0.81 | HTR2A (0.51) | HTR2AHTR2CCDK4CCND1PRMT5 | |
| SCHEMBL17676473 | 0.80 | HTR2A (0.58) | HTR2AHTR2CCDK4CCND1MAPT | |
| SCHEMBL11622820 | 0.78 | HTR2A (0.57) | HTR2AHTR2CCDK4CCND1MAPT | |
| SCHEMBL13444442 | 0.77 | HTR2C (0.64) | HTR2AHTR2CCDK4CCND1MAPT | |
| SCHEMBL18856946 | 0.77 | HTR2A (0.55) | HTR2AHTR2CCDK4CCND1MAPT | |
| SCHEMBL29379279 | 0.76 | CDK4 (0.68) | HTR2AHTR2CCDK4CCND1 | |
| SCHEMBL3471412 | 0.76 | CDK4 (0.68) | HTR2AHTR2CCDK4CCND1 | |
| SCHEMBL22911457 | 0.76 | PLG (0.47) | PLGPLAU | |
| SCHEMBL11084225 | 0.75 | HTR2A (0.62) | HTR2AHTR2CCDK4CCND1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5440046-A | Angiotensin antagonist, hypotensive agent | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-08-08 | — | — | US | disclosed |
| EP-0450566-B1 | Substituted azoles, method for their preparation, these containing compositions and their use | HOECHST AG (DE) | 1995-07-05 | — | — | EP | disclosed |
| US-5350751-A | Hypotensive agents | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-09-27 | — | — | US | disclosed |
| EP-0450566-A1 | Substituted azoles, method for their preparation, these containing compositions and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-09 | — | — | EP | disclosed |