Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.36 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11651632 | 0.77 | SLC6A4 (0.47) | MEN1KMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL16321190 | 0.76 | KMT2A (0.41) | MEN1KMT2AMAPTLMNACYP2C19 | |
| SCHEMBL16321189 | 0.76 | KMT2A (0.41) | MEN1KMT2AMAPTLMNACYP2C19 | |
| SCHEMBL11650115 | 0.76 | MEN1 (0.42) | MEN1KMT2AMAPTLMNADDB1 | |
| SCHEMBL9419046 | 0.73 | MAPT (0.49) | MEN1KMT2AMAPTLMNACYP2D6 | |
| SCHEMBL11652243 | 0.72 | MEN1 (0.42) | MEN1KMT2AMAPTLMNADDB1 | |
| SCHEMBL11653597 | 0.72 | MEN1 (0.56) | MEN1KMT2AMAPTLMNAOPRL1 | |
| SCHEMBL5014355 | 0.72 | MEN1 (0.51) | MEN1KMT2AMAPTLMNADDB1 | |
| SCHEMBL8161476 | 0.70 | MEN1 (0.37) | MEN1KMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11654111 | 0.70 | MAPT (0.39) | MEN1KMT2ASLC6A2SLC6A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3836940-A1 | METHODS AND COMPOSITIONS FOR REDUCING FLUOROURACIL INDUCED TOXICITY | Tosk, Inc. (US) | 2021-06-23 | — | — | EP | disclosed |
| WO-2020036975-A1 | METHODS AND COMPOSITIONS FOR REDUCING FLUOROURACIL INDUCED TOXICITY | TOSK, INC. (US) | 2020-02-20 | — | — | WO | disclosed |
| EP-0526537-B1 | 5-BENZYL BARBITURATE DERIVATIVES | UNIV BROWN RES FOUND (US) | 1995-07-12 | — | — | EP | disclosed |
| EP-0526537-A1 | 5-BENZYL BARBITURATE DERIVATIVES. | UNIV BROWN RES FOUND (US) | 1993-02-10 | — | — | EP | disclosed |
| US-5141943-A | Water soluble uridine phosphorylase inhibitors, reducing toxicity and anemia of antiviral drugs | BROWN UNIVERSITY RESEARCH FOUNDATION (US) | 1992-08-25 | — | — | US | disclosed |
| WO-1991016315-A1 | 5-BENZYL BARBITURATE DERIVATIVES | BROWN UNIVERSITY RESEARCH FOUNDATION (US) | 1991-10-31 | — | — | WO | disclosed |