Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2567001 | 0.89 | PDF (0.48) | MAPTMEN1KMT2AALDH1A1HDAC3 | |
| SCHEMBL591280 | 0.88 | NPC1 (0.51) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL2936175 | 0.88 | NPC1 (0.51) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL701212 | 0.88 | NPC1 (0.51) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL8002080 | 0.88 | NPC1 (0.42) | MAPTMEN1KMT2ANPC1RAB9A | |
| Hydrochloric Acid SCHEMBL10768387 | 0.87 | NPC1 (0.50) | MAPTMEN1KMT2ANPC1RAB9A | |
| Hydrochloric Acid SCHEMBL2044745 | 0.87 | NPC1 (0.50) | MAPTMEN1KMT2ANPC1RAB9A | |
| Hydrochloric Acid SCHEMBL593062 | 0.87 | NPC1 (0.50) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL1517668 | 0.86 | NPC1 (0.41) | MEN1KMT2ANPC1RAB9AMITF | |
| Hydrochloric Acid SCHEMBL5847438 | 0.86 | NPC1 (0.40) | MEN1KMT2ANPC1RAB9AMITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5427931-A | Useful in the treatment and detection of Alzheimer's disease | THEN REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0527823-A4 | — | — | 1994-04-06 | — | — | EP | disclosed |
| US-5270165-A | Diagnosing Alzheimer's disease | THE REAGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0527823-A1 | PURIFICATION, DETECTION AND METHODS OF USE OF PROTEASE NEXIN-2 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1993-02-24 | — | — | EP | disclosed |