Sugi Predict

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PDF

Peptide deformylase, mitochondrial · Q9HBH1 · PDF on Sugi Atlas →

3,800 patent compounds predicted against PDF, 1,658 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL290557 SCHEMBL290557 0.72 13/20
SCHEMBL289640 SCHEMBL289640 0.70 13/20
SCHEMBL290072 SCHEMBL290072 1.00 12/20
SCHEMBL801251 SCHEMBL801251 0.82 12/20
SCHEMBL290433 SCHEMBL290433 0.77 12/20
SCHEMBL291008 SCHEMBL291008 0.75 12/20
SCHEMBL801888 SCHEMBL801888 0.73 12/20
SCHEMBL805352 SCHEMBL805352 0.62 12/20
SCHEMBL805350 SCHEMBL805350 0.61 12/20
SCHEMBL805348 SCHEMBL805348 0.60 12/20
SCHEMBL801781 SCHEMBL801781 0.49 12/20
SCHEMBL289618 SCHEMBL289618 1.00 11/20
SCHEMBL290142 SCHEMBL290142 1.00 11/20
SCHEMBL290290 SCHEMBL290290 1.00 11/20
SCHEMBL290717 SCHEMBL290717 1.00 11/20
SCHEMBL290169 SCHEMBL290169 0.82 11/20
SCHEMBL289946 SCHEMBL289946 0.77 11/20
SCHEMBL801241 SCHEMBL801241 0.73 11/20
SCHEMBL801804 SCHEMBL801804 0.72 11/20
SCHEMBL801229 SCHEMBL801229 0.71 11/20

Clinical trials — most relevant to PDF by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Depakote (Divalproex Sodium) for Children With Temper Dysregulation and Severe Mood Swings PHASE4COMPLETED
Deoxynucleosides Pyrimidines as Treatment for Mitochondrial Depletion Syndrome PHASE2RECRUITING
A Study of Bezafibrate in Mitochondrial Myopathy PHASE2COMPLETED
Thyroid Hormone for Treatment of Nonalcoholic Steatohepatitis in Veterans PHASE2RECRUITING
Relative Mitochondrial Toxicity of Tenofovir Alafenamide (TAF) vs. Tenofovir Disoproxil Fumarate (TDF) PHASE1/PHASE2COMPLETED
Exploring the Relationship Between Androgen Metabolism, Metabolic Disease and Skeletal Muscle Energy Balance in Men nanUNKNOWN
Nicotinamide Riboside and Mitochondrial Biogenesis nanCOMPLETED
Effect of Branched Chain Amino Acids on Muscle nanCOMPLETED
Natural History and Advanced Genetic Study of Pyruvate Dehydrogenase Complex Deficiencies nanRECRUITING
Mitochondrial Assessment in Critical Ill Patients in Intensive Care nanNOT_YET_RECRUITING
Measures of Mitochondria Dysfunction in PD nanUNKNOWN
Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders nanRECRUITING
Effect of Diaphragm Stimulation During Surgery nanCOMPLETED
Impact of Iron Deficiency and Its Correction on Mitochondrial Metabolism of the Cardiomyocyte (MitoCardioFer) nanCOMPLETED
Skeletal Muscle Apoptosis and Physical Performance; Oxidative RNA/DNA Damage and Repair in Aged Human Muscle nanCOMPLETED
Mitochondrial Video Assessment Source Material Study nanCOMPLETED
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy nanRECRUITING
Human Mitochondrial Stress-driven Obesity Resistance nanCOMPLETED
Mitochondrial Dysfunction in Diabetes nanCOMPLETED
Energy Requirements in Mitochondrial Disease nanCOMPLETED
Diagnostic Odyssey Survey 2 nanCOMPLETED
Cardiac Mitochondrial Function in Explanted Human Hearts nanUNKNOWN
The Natural History of Mitochondrial Diseases nanRECRUITING
Fatty Acid Oxidation Defects and Insulin Sensitivity nanCOMPLETED
Aging and the Mitochondrial Response to Exercise Training, Measured by Noninvasive 31P Magnetic Resonance Spectroscopy nanCOMPLETED
ACTIV- Exercise Intervention in Healthy Young Men nanCOMPLETED
Metabolic Control of Aging and Disease - the MetAGE Deep Phenotyping Cohort nanRECRUITING
Multiple Sclerosis: The Role of Mitochondrial Dysfunction in IR Resistance nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a PDF binder may also engage these)

ProteinNameSimilarity
S4R2K0 — 1.000 S4R2K0 →
Q8N2A8 — 0.951 Q8N2A8 →
PKN3 Serine/threonine-protein kinase N3 0.947 landscape →
E2RD63 — 0.946 E2RD63 →
Q4FZD7 — 0.946 Q4FZD7 →
Q2TA57 — 0.945 Q2TA57 →
Q5EA03 — 0.945 Q5EA03 →
MRM1 rRNA methyltransferase 1, mitochondrial 0.945 landscape →
Q6PJN8 — 0.945 Q6PJN8 →
A1L515 — 0.945 A1L515 →
Q9JIA7 — 0.945 Q9JIA7 →
Q9DD16 — 0.945 Q9DD16 →
G5E872 — 0.944 G5E872 →
Q5U4P2 — 0.944 Q5U4P2 →
Q96NS5 — 0.944 Q96NS5 →
SPHK2 Sphingosine kinase 2 0.944 landscape →
Q5EBM0 — 0.944 Q5EBM0 →
Q8HZR3 — 0.944 Q8HZR3 →
Q0VC80 — 0.943 Q0VC80 →
Q91ZT7 — 0.943 Q91ZT7 →
Q5D0E6 — 0.943 Q5D0E6 →
A6QQD2 — 0.943 A6QQD2 →
P70295 — 0.943 P70295 →
Q8K045 — 0.943 Q8K045 →
A6QP75 — 0.942 A6QP75 →
Q86U90 — 0.942 Q86U90 →
Q96EY9 — 0.942 Q96EY9 →
Q9BQD7 — 0.942 Q9BQD7 →
Q6P9U1 — 0.942 Q6P9U1 →
PKN1 Serine/threonine-protein kinase N1 0.942 landscape →