Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 2/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | HRH1 | P35367 | 3/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL628167 | 0.97 | DPP4 (0.47) | DPP4F2TSHRHTR2AHRH1 | |
| SCHEMBL27552354 | 0.93 | DPP4 (0.45) | DPP4F2TSHRHTR2AHRH1 | |
| SCHEMBL28698472 | 0.93 | DPP4 (0.45) | DPP4F2TSHRHTR2AHRH1 | |
| SCHEMBL27551062 | 0.93 | DPP4 (0.45) | DPP4F2TSHRHTR2AHRH1 | |
| SCHEMBL31378181 | 0.93 | DPP4 (0.45) | DPP4F2TSHRHTR2AHRH1 | |
| Hydrochloric Acid SCHEMBL1236348 | 0.93 | TDP1 (0.46) | DPP4F2TSHRHTR2AHRH1 | |
| SCHEMBL8585010 | 0.93 | DPP4 (0.45) | DPP4F2TSHRHTR2AHRH1 | |
| Iodide SCHEMBL28347317 | 0.93 | DPP4 (0.45) | DPP4F2TSHRHTR2AHRH1 | |
| SCHEMBL28859133 | 0.93 | DPP4 (0.45) | DPP4F2TSHRHTR2AHRH1 | |
| SCHEMBL27967470 | 0.93 | DPP4 (0.45) | DPP4F2TSHRHTR2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024097744-A2 | DNA-COMPATIBLE WITTIG OLEFINATION OF ON-DNA PEPTIDYL-YLIDES FOR DEVELOPMENT OF ON-DNA PEPTIDOMIMETICS THROUGH DIVERSITY-ORIENTED SYNTHESIS (DOS) | THE ROCKEFELLER UNIVERSITY (US) | 2024-05-10 | — | — | WO | disclosed |
| CN-106276966-B | A kind of alkali metal-free system synthetic method of transgranular phosphorous ZSM-5 molecular sieve | 中国石油化工股份有限公司 | 2019-03-22 | — | — | CN | disclosed |
| US-5389486-A | A mixtures consisting of a binders and a colorless phosphonium compounds charge control agents; metal-free, stability, good dispersibility in binders; copying machine | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1995-02-14 | — | — | US | disclosed |
| US-4892949-A | ORGANIC PHOTOCONDUCTORS | RICOH COMPANY, LTD. (JP) | 1990-01-09 | — | — | US | disclosed |
| US-4859556-A | MULTILAYER; ELECTROCONDUCTIVE SUPPORT WITH PHOTOSENSITIVE MATERIAL | RICOH COMPANY, LTD. (JP) | 1989-08-22 | — | — | US | disclosed |