Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | PLA2G7 | Q13093 | 3/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 3/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9185198 | 1.00 | TRPV4 (0.42) | TRPV4CYP11B1CYP11B2GPR119PLA2G7 | |
| SCHEMBL9349206 | 0.99 | TRPV4 (0.41) | TRPV4CYP11B1CYP11B2GPR119PLA2G7 | |
| SCHEMBL9589888 | 0.99 | TRPV4 (0.41) | TRPV4CYP11B1CYP11B2GPR119PLA2G7 | |
| SCHEMBL9349103 | 0.99 | TRPV4 (0.41) | TRPV4CYP11B1CYP11B2GPR119PLA2G7 | |
| SCHEMBL9346478 | 0.99 | TRPV4 (0.41) | TRPV4CYP11B1CYP11B2GPR119PLA2G7 | |
| SCHEMBL9346370 | 0.99 | TRPV4 (0.41) | TRPV4CYP11B1CYP11B2GPR119PLA2G7 | |
| SCHEMBL9344960 | 0.99 | TRPV4 (0.41) | TRPV4CYP11B1CYP11B2GPR119PLA2G7 | |
| SCHEMBL9591934 | 0.99 | TRPV4 (0.41) | TRPV4CYP11B1CYP11B2GPR119PLA2G7 | |
| SCHEMBL9590952 | 0.99 | TRPV4 (0.41) | TRPV4CYP11B1CYP11B2GPR119PLA2G7 | |
| SCHEMBL9591456 | 0.99 | TRPV4 (0.41) | TRPV4CYP11B1CYP11B2GPR119PLA2G7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0423520-B1 | Liquid crystalline composition for the use in a twisted nematic cell | MERCK PATENT GMBH (DE) | 1995-08-02 | — | — | EP | disclosed |
| EP-0344557-B1 | Liquid crystal components with a trimethylenoxy group | HOFFMANN LA ROCHE (CH) | 1994-08-10 | — | — | EP | disclosed |
| US-5238600-A | IBIMETHYLENOXY CONTAINING LIQUID CRYSTAL COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 1993-08-24 | — | — | US | disclosed |
| EP-0423520-A2 | Liquid crystalline composition for the use in a twisted nematic cell | MERCK PATENT GmbH (DE) | 1991-04-24 | — | — | EP | disclosed |
| EP-0344557-A2 | Liquid crystal components with a trimethylenoxy group | F. HOFFMANN-LA ROCHE AG (CH) | 1989-12-06 | — | — | EP | disclosed |