Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 2/20 | 0.53 |
| ▸ | DHODH | Q02127 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9186302 | 0.95 | XDH (0.47) | XDHDHODHALDH1A1MEN1KMT2A | |
| SCHEMBL9182543 | 0.88 | DHODH (0.43) | XDHDHODHALDH1A1MEN1KMT2A | |
| SCHEMBL9187036 | 0.87 | GAK (0.44) | XDHDHODHALDH1A1MEN1KMT2A | |
| SCHEMBL9183532 | 0.85 | SMN1; SMN2 (0.48) | ALDH1A1MEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL1744281 | 0.84 | MEN1 (0.53) | ALDH1A1MEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL9263478 | 0.84 | XDH (0.59) | XDHDHODHALDH1A1MEN1KMT2A | |
| SCHEMBL9547659 | 0.84 | XDH (0.53) | XDHDHODHALDH1A1MEN1KMT2A | |
| SCHEMBL9180522 | 0.84 | PDE4D (0.41) | XDHDHODHALDH1A1GAASMN1; SMN2 | |
| SCHEMBL9179120 | 0.83 | MAPT (0.43) | ALDH1A1MEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL9183215 | 0.82 | SMN1; SMN2 (0.43) | ALDH1A1MEN1KMT2AMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0469013-B1 | NOVEL ARYLPYRIDAZINES, THEIR MANUFACTURE, USE AND MEDICAMENTS CONTAINING THEM | BYK GULDEN LOMBERG CHEM FAB (DE) | 1995-06-28 | — | — | EP | disclosed |
| US-5236918-A | Bronchial disorders | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1993-08-17 | — | — | US | disclosed |
| WO-1990012789-A1 | NOVEL ARYLPYRIDAZINES, THEIR MANUFACTURE, USE AND MEDICAMENTS CONTAINING THEM | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1990-11-01 | — | — | WO | disclosed |
| EP-0393500-A1 | Arylpyridazines, their preparation, their use and pharmaceuticals containing them | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1990-10-24 | — | — | EP | disclosed |
| US-4707481-A | Pyridazinones, their preparation and use, and bronchospasmolytic medicaments containing pyridazinones | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1987-11-17 | — | — | US | disclosed |
| EP-0125636-B1 | PYRIDAZINONES, THEIR PREPARATION AND USE, MEDICINES CONTAINING THESE PYRIDAZINONES | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1987-04-01 | — | — | EP | disclosed |
| WO-1984004521-A1 | PYRIDAZINONES, THEIR PREPARATION AND USE, AND MEDICAMENTS CONTAINING PYRIDAZINONES | BYK GULDEN LOMBERG CHEM FAB (DE) | 1984-11-22 | — | — | WO | disclosed |
| EP-0125636-A1 | Pyridazinones, their preparation and use, medicines containing these pyridazinones | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1984-11-21 | — | — | EP | disclosed |