Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 7/20 | 0.75 |
| ▸ | CYP1A1 | P04798 | 6/20 | 0.75 |
| ▸ | CYP1B1 | Q16678 | 6/20 | 0.75 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.69 |
| ▸ | TUBB | P07437 | 5/20 | 0.69 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.69 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.69 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.69 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.69 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.69 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.69 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.69 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.69 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.69 |
| ▸ | TUBA1C | Q9BQE3 | 5/20 | 0.69 |
| ▸ | TUBB6 | Q9BUF5 | 5/20 | 0.69 |
| ▸ | TUBB2B | Q9BVA1 | 5/20 | 0.69 |
| ▸ | TUBB1 | Q9H4B7 | 5/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9185976 | 1.00 | CYP1A2 (0.75) | CYP1A2CYP1A1CYP1B1TUBB4ATUBB | |
| SCHEMBL15288715 | 0.86 | CYP1A2 (1.00) | CYP1A2CYP1A1CYP1B1TUBB4ATUBB | |
| SCHEMBL15288712 | 0.86 | CYP1A2 (1.00) | CYP1A2CYP1A1CYP1B1TUBB4ATUBB | |
| SCHEMBL9184894 | 0.83 | CYP1A1 (0.57) | CYP1A2CYP1A1CYP1B1TUBB4ATUBB | |
| SCHEMBL9184888 | 0.83 | CYP1A1 (0.57) | CYP1A2CYP1A1CYP1B1TUBB4ATUBB | |
| SCHEMBL5071920 | 0.82 | TUBB4A (1.00) | CYP1A2CYP1A1CYP1B1TUBB4ATUBB | |
| SCHEMBL5073619 | 0.82 | CYP1A2 (0.75) | CYP1A2CYP1A1CYP1B1TUBB4ATUBB | |
| SCHEMBL5071915 | 0.82 | TUBB4A (1.00) | CYP1A2CYP1A1CYP1B1TUBB4ATUBB | |
| SCHEMBL5073636 | 0.82 | CYP1A2 (0.75) | CYP1A2CYP1A1CYP1B1TUBB4ATUBB | |
| SCHEMBL19275938 | 0.79 | TUBB4A (0.78) | CYP1A2CYP1A1CYP1B1TUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5430062-A | Combretastatin analogues; inhibition of tubulin polymerization and colchicine binding; antitumor,-mitotic and -neoplastic agents | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1995-07-04 | — | — | US | claimed |