Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 17/20 | 0.64 |
| ▸ | RXRB | P28702 | 11/20 | 0.64 |
| ▸ | RXRG | P48443 | 10/20 | 0.64 |
| ▸ | RARB | P10826 | 6/20 | 0.42 |
| ▸ | RARG | P13631 | 5/20 | 0.42 |
| ▸ | RARA | P10276 | 3/20 | 0.42 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.40 |
| ▸ | CYP26B1 | Q9NR63 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18741055 | 0.90 | RXRA (0.52) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL18741265 | 0.84 | RXRA (0.52) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL6281772 | 0.81 | RXRA (0.50) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL3298635 | 0.80 | RXRA (0.61) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL6244149 | 0.78 | RXRA (1.00) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL6275679 | 0.78 | RXRA (0.47) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL4417565 | 0.78 | RXRA (0.52) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL6908129 | 0.77 | RXRA (0.59) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL10842818 | 0.77 | RARB (0.74) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL10844307 | 0.77 | RARB (0.74) | RXRARXRBRXRGRARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5475017-A | Skin disorders, antitumor agents; side effect reduction | BASF AKTIENGESELLSCHAFT (DE) | 1995-12-12 | — | — | US | disclosed |
| US-5338749-A | Treating rheumatic or arthritic disorders | BASF AKTIENGESELLSCHAFT (DE) | 1994-08-16 | — | — | US | disclosed |
| US-5326900-A | Aromatic keto compounds, the preparation thereof, and drugs and cosmetics containing these | BASF AKTIENGESELLSCHAFT (DE) | 1994-07-05 | — | — | US | disclosed |
| US-5256694-A | For skin disorders; carcinomas | BASF AKTIENGESELLSCHAFT (DE) | 1993-10-26 | — | — | US | disclosed |
| EP-0382078-B1 | AROMATIC KETO COMPOUNDS, THEIR PREPARATION AND MEDICINAL AS WELL AS COSMETIC PREPARATIONS CONTAINING THEM | BASF Aktiengesellschaft (DE) | 1993-09-22 | — | — | EP | disclosed |
| US-5206242-A | Skin disorders | BASF AKTIENGESELLSCHAFT (DE) | 1993-04-27 | — | — | US | disclosed |
| US-5196532-A | Treatment of skin disorders | BASF AKTIENGESELLSCHAFT (DE) | 1993-03-23 | — | — | US | disclosed |
| US-5194664-A | Aromatic keto compounds, the preparation thereof, and drugs and cosmetics containing these | BASF AKTIENGESELLSCHAFT (DE) | 1993-03-16 | — | — | US | disclosed |
| US-5126371-A | Precancerous skin conditions, acne, psoriasis | BASF AKTEINGESELLSCHAFT (DE) | 1992-06-30 | — | — | US | disclosed |
| US-5061705-A | Skin disorders | BASF AKTIENGESELLSCHAFT (DE) | 1991-10-29 | — | — | US | disclosed |
| US-4994489-A | Ester derivatives of diarylacetylenes, their compositions and their use in acne treatment | BASF AKTIENGESELLSCHAFT | 1991-02-19 | — | — | US | disclosed |
| EP-0382078-A1 | Aromatic keto compounds, their preparation and medicinal as well as cosmetic preparations containing them | BASF Aktiengesellschaft (DE) | 1990-08-16 | — | — | EP | disclosed |
| EP-0176034-B1 | DIARYL ACETYLENES, THEIR PREPARATION AND USE | BASF Aktiengesellschaft (DE) | 1989-08-30 | — | — | EP | disclosed |
| US-4806558-A | Diarylacetylenes and their use in treating acne | BASF AKTIENGESELLSCHAFT (DE) | 1989-02-21 | — | — | US | disclosed |
| EP-0176034-A2 | Diaryl acetylenes, their preparation and use | BASF Aktiengesellschaft (DE) | 1986-04-02 | — | — | EP | disclosed |