Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of 2-Ethoxyethanol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.74 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Ethoxyethanol SCHEMBL11589198 | 1.00 | ALDH1A1 (0.74) | ALDH1A1TSHRMAPK1THRBKMT2A | |
| 2-Ethoxyethanol SCHEMBL11662758 | 1.00 | ALDH1A1 (0.74) | ALDH1A1TSHRMAPK1THRBKMT2A | |
| 2-Ethoxyethanol SCHEMBL1355783 | 1.00 | ALDH1A1 (0.74) | ALDH1A1TSHRMAPK1THRBKMT2A | |
| 2-Ethoxyethanol SCHEMBL11335066 | 1.00 | ALDH1A1 (0.74) | ALDH1A1TSHRMAPK1THRBKMT2A | |
| Diethylene Glycol Monoethyl Ether SCHEMBL6274024 | 0.95 | ALDH1A1 (0.67) | ALDH1A1TSHRMAPK1THRBKMT2A | |
| Diethylene Glycol Monoethyl Ether SCHEMBL6389344 | 0.95 | ALDH1A1 (0.67) | ALDH1A1TSHRMAPK1THRBKMT2A | |
| Diethylene Glycol Monoethyl Ether SCHEMBL10526576 | 0.95 | ALDH1A1 (0.67) | ALDH1A1TSHRMAPK1THRBKMT2A | |
| Diethylene Glycol Monoethyl Ether SCHEMBL11391688 | 0.95 | ALDH1A1 (0.67) | ALDH1A1TSHRMAPK1THRBKMT2A | |
| Diethylene Glycol Monoethyl Ether SCHEMBL11232463 | 0.95 | ALDH1A1 (0.67) | ALDH1A1TSHRMAPK1THRBKMT2A | |
| Acetic Acid SCHEMBL27658128 | 0.95 | ALDH1A1 (0.67) | ALDH1A1TSHRMAPK1THRBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5391465-A | Using phenothiazine or phenoxazine compounds | ROHM AND HAAS COMPANY (US) | 1995-02-21 | — | — | US | disclosed |
| US-4623392-A | RELEASE COATINGS | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1986-11-18 | — | — | US | disclosed |