Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 4/20 | 0.70 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.43 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | LTK | P29376 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | PRKX | P51817 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.43 |
| ▸ | STK3 | Q13188 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16741993 | 0.83 | DHODH (0.70) | DHODHKMT2AHTTTSHRLMNA | |
| SCHEMBL5049041 | 0.83 | DHODH (0.70) | DHODHKMT2AHTTTSHRLMNA | |
| SCHEMBL27242987 | 0.83 | DHODH (0.74) | DHODHKMT2ATP53CYP3A4HTT | |
| SCHEMBL25813258 | 0.83 | DHODH (0.74) | DHODHKMT2ATP53CYP3A4HTT | |
| SCHEMBL6655226 | 0.83 | DHODH (0.70) | DHODHKMT2AHTTTSHRLMNA | |
| SCHEMBL18118641 | 0.83 | DHODH (0.70) | DHODHKMT2ATP53HTTTSHR | |
| SCHEMBL18120682 | 0.82 | DHODH (1.00) | DHODHEPHX2 | |
| SCHEMBL8857884 | 0.82 | DHODH (1.00) | DHODHEPHX2 | |
| SCHEMBL8678233 | 0.82 | DHODH (0.68) | DHODHKMT2AHTTTSHRLMNA | |
| SCHEMBL8614000 | 0.82 | DHODH (0.68) | DHODHKMT2ALMNAMEN1G6PD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0606175-B1 | 2-Cyano-3-hydroxypropenamide derivatives, process for their preparation, their use as medicaments and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1995-10-11 | — | — | EP | claimed |
| EP-0606175-A1 | 2-Cyano-3-hydroxypropenamide derivatives, process for their preparation, their use as medicaments and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1994-07-13 | — | — | EP | claimed |
| EP-0606175-B1 | 2-Cyano-3-hydroxypropenamide derivatives, process for their preparation, their use as medicaments and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1995-10-11 | — | — | EP | disclosed |
| US-5346912-A | 2-cyano-3-hydroxy-(n-pyridyl)-propenamide compounds | ROUSSEL-UCLAF (FR) | 1994-09-13 | — | — | US | disclosed |
| EP-0606175-A1 | 2-Cyano-3-hydroxypropenamide derivatives, process for their preparation, their use as medicaments and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1994-07-13 | — | — | EP | disclosed |