Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 2/20 | 0.44 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9183329 | 0.86 | PPARG (0.44) | PPARGLMNATSHRHTTALOX15 | |
| SCHEMBL9188431 | 0.83 | PPARG (0.42) | PPARGNR1H4HDAC8HDAC6HDAC11 | |
| SCHEMBL9182479 | 0.82 | PPARG (0.43) | PPARGLMNATSHRHTTHDAC8 | |
| SCHEMBL9187696 | 0.76 | PPARG (0.42) | PPARGNR1H4HDAC8HDAC6HDAC11 | |
| SCHEMBL30185512 | 0.76 | PLAU (0.56) | PPARGPLAUPLGNR1H4HDAC8 | |
| SCHEMBL28580033 | 0.76 | PLAU (0.56) | PPARGPLAUPLGNR1H4HDAC8 | |
| SCHEMBL9186891 | 0.75 | PPARG (0.45) | PPARGEPHX2 | |
| SCHEMBL15971036 | 0.75 | PLAU (0.57) | PPARGPLAUPLGHDAC8HDAC6 | |
| SCHEMBL30888879 | 0.75 | PLAU (0.57) | PPARGPLAUPLGHDAC8HDAC6 | |
| SCHEMBL9189437 | 0.75 | PLA2G4A (0.40) | PPARGNR1H4HDAC8HDAC6HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0476935-B1 | New indol and indoline derivatives | LILLY INDUSTRIES LTD (GB) | 1995-07-26 | — | — | EP | disclosed |
| US-5185361-A | Indole sulfonamides; Leukotriene antagonists | LILLY INDUSTRIES LIMITED (GB) | 1993-02-09 | — | — | US | disclosed |
| EP-0476935-A1 | New indol and indoline derivatives | LILLY INDUSTRIES LIMITED (GB) | 1992-03-25 | — | — | EP | disclosed |