⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7797193 | 0.82 | PPARG (0.32) | — | |
| SCHEMBL401757 | 0.78 | — | — | |
| SCHEMBL21955629 | 0.68 | — | — | |
| SCHEMBL6577421 | 0.67 | — | — | |
| SCHEMBL8388914 | 0.62 | PTPN1 (0.36) | — | |
| SCHEMBL9706974 | 0.62 | — | — | |
| SCHEMBL30344962 | 0.62 | — | — | |
| SCHEMBL29478293 | 0.62 | — | — | |
| SCHEMBL7598535 | 0.62 | — | — | |
| SCHEMBL17441373 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159521-A1 | 1H-PYRAZOLO[4,3-G]ISOQUINOLINE AND 1H-PYRAZOLO[4,3-G]QUINOLINE DERIVATIVES AS ALPHA-1-ANTITRYPSIN MODULATORS FOR TREATING ALPHA-1-ANTITRYPSIN DEFICIENCY (AATD) | VERTEX PHARMACEUTICALS INCORPORATED | 2023-05-25 | — | — | US | disclosed |
| US-20230159521-A1 | 1H-PYRAZOLO[4,3-G]ISOQUINOLINE AND 1H-PYRAZOLO[4,3-G]QUINOLINE DERIVATIVES AS ALPHA-1-ANTITRYPSIN MODULATORS FOR TREATING ALPHA-1-ANTITRYPSIN DEFICIENCY (AATD) | VERTEX PHARMACEUTICALS INCORPORATED | 2023-05-25 | — | — | US | disclosed |
| US-11571419-B2 | Lanthionine synthetase C-like 2-based therapeutics | LANDOS BIOPHARMA, INC. (US) | 2023-02-07 | — | — | US | disclosed |
| US-11197891-B2 | Therapies with lanthionine C-like protein 2 ligands and cells prepared therewith | LANDOS BIOPHARMA, INC. (US) | 2021-12-14 | — | — | US | disclosed |
| US-20210046070-A1 | LANTHIONINE SYNTHETASE C-LIKE 2-BASED THERAPEUTICS | LANDOS BIOPHARMA, INC. (US) | 2021-02-18 | — | — | US | disclosed |
| US-10849895-B2 | Lanthionine synthetase C-like 2-based therapeutics | LANDOS BIOPHARMA, INC. (US) | 2020-12-01 | — | — | US | disclosed |
| US-20200261447-A1 | LANTHIONINE SYNTHETASE C-LIKE 2-BASED THERAPEUTICS | LANDOS BIOPHARMA, INC. (US) | 2020-08-20 | — | — | US | disclosed |
| US-10682349-B2 | Lanthionine synthetase C-like 2-based therapeutics | LANDOS BIOPHARMA, INC. (US) | 2020-06-16 | — | — | US | disclosed |
| US-20200046694-A1 | LANTHIONINE SYNTHETASE C-LIKE 2-BASED THERAPEUTICS | LANDOS BIOPHARMA, INC. (US) | 2020-02-13 | — | — | US | disclosed |
| US-20190160100-A1 | THERAPIES WITH LANTHIONINE C-LIKE PROTEIN 2 LIGANDS AND CELLS PREPARED THEREWITH | LANDOS BIOPHARMA, INC. (US) | 2019-05-30 | — | — | US | disclosed |
| US-20160115153-A1 | LANTHIONINE SYNTHETASE C-LIKE 2-BASED THERAPEUTICS | BIOTHERAPEUTICS, INC. (US) | 2016-04-28 | — | — | US | disclosed |
| US-9254272-B2 | Resorcinol derivatives | SUTTER WEST BAY HOSPITALS (US) | 2016-02-09 | — | — | US | disclosed |
| US-20130209483-A1 | CANNABIDINOID DERIVATIVES | SUTTER WEST BAY HOSPITALS (US) | 2013-08-15 | — | — | US | disclosed |
| US-8003662-B2 | Heterobicyclic thiophene compounds and methods of use | ARRAY BIOPHARMA, INC. (US) | 2011-08-23 | — | — | US | disclosed |
| US-20110009560-A1 | ETHYLENICALLY UNSATURATED MONOMERS COMPRISING ALIPHATIC AND AROMATIC MOIETIES | DOW GLOBAL TECHNOLOGIES INC. (US) | 2011-01-13 | — | — | US | disclosed |
| US-20070197537-A1 | Heterobicyclic thiophene compounds and methods of use | ARRAY BIOPHARMA, INC. | 2007-08-23 | — | — | US | disclosed |
| EP-0612783-B1 | Cyanate resin composition and copper-clad laminate | SUMITOMO CHEMICAL CO (JP) | 1999-05-06 | — | — | EP | disclosed |
| US-5563237-A | INCLUDES A BISMALEIMIDE HARDENER | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1996-10-08 | — | — | US | disclosed |
| EP-0612783-A1 | Cyanate resin composition and copper-clad laminate | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993002074-A1 | ALKOXYAMINO KETALS, THEIR PREPARATION AND INTERMEDIATE PRODUCTS THEREFOR, AND THEIR USE AS FUNGICIDES | CHEMINOVA AGRO A/S (DK) | 1993-02-04 | — | — | WO | disclosed |