Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 7/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.37 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | FAP | Q12884 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4459733 | 0.75 | HRH3 (0.45) | — | |
| SCHEMBL488953 | 0.75 | DPP4 (0.64) | HPGDDPP4DPP8DPP9L3MBTL1 | |
| SCHEMBL1383434 | 0.75 | DPP4 (0.64) | HPGDDPP4DPP8DPP9L3MBTL1 | |
| SCHEMBL488954 | 0.75 | DPP4 (0.64) | HPGDDPP4DPP8DPP9L3MBTL1 | |
| SCHEMBL351910 | 0.74 | MEN1 (0.63) | MEN1BLMKMT2ATSHR | |
| SCHEMBL17943259 | 0.74 | MEN1 (0.63) | MEN1BLMKMT2ATSHR | |
| SCHEMBL2964298 | 0.74 | MEN1 (0.63) | MEN1BLMKMT2ATSHR | |
| SCHEMBL2964302 | 0.74 | MEN1 (0.63) | MEN1BLMKMT2ATSHR | |
| SCHEMBL12909421 | 0.74 | MEN1 (0.63) | MEN1BLMKMT2ATSHR | |
| SCHEMBL3260294 | 0.74 | MEN1 (0.63) | MEN1BLMKMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0361791-B1 | Azacyclic derivatives useful as medicaments | SMITHKLINE BEECHAM FARMA (IT) | 1995-11-08 | — | — | EP | disclosed |
| US-5089507-A | Also diuretic; long lasting, side effect reduction | DR. L. ZAMBELETTI SPA (IT) | 1992-02-18 | — | — | US | disclosed |
| EP-0447704-A1 | N-Acylated azacyclic compounds, processes for their preparations and their use as medications | Smithkline Beecham Farmaceutici S.p.A. (IT) | 1991-09-25 | — | — | EP | disclosed |
| EP-0361791-A2 | Azacyclic derivatives useful as medicaments | Smithkline Beecham Farmaceutici S.p.A. (IT) | 1990-04-04 | — | — | EP | disclosed |