SCHEMBL9190607

SCHEMBL9190607

CCCC(=O)C(C)(O)C(F)(F)F

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CES1 P23141 6/20 0.43
CES2 O00748 3/20 0.43
FAAH O00519 8/20 0.41
MEN1 O00255 1/20 0.40
CYP1A2 P05177 1/20 0.40
KMT2A Q03164 1/20 0.40
HSD17B10 Q99714 1/20 0.40
FFAR3 O14843 3/20 0.36
HDAC3 O15379 3/20 0.36
HDAC1 Q13547 3/20 0.36
HDAC2 Q92769 3/20 0.36
HDAC8 Q9BY41 3/20 0.36
TSHR P16473 1/20 0.35
PDK1 Q15118 1/20 0.33
PDK2 Q15119 1/20 0.33
PDK3 Q15120 1/20 0.33
PDK4 Q16654 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9186046 0.86 FAAH (0.54) CES1CES2FAAHMEN1CYP1A2
SCHEMBL9192108 0.85 FAAH (0.63) CES1CES2FAAHMEN1CYP1A2
SCHEMBL9186016 0.83 FAAH (0.64) CES1CES2FAAHMEN1CYP1A2
SCHEMBL9192948 0.83 FAAH (0.64) CES1CES2FAAHMEN1CYP1A2
SCHEMBL9188755 0.83 FAAH (0.64) CES1CES2FAAHMEN1CYP1A2
SCHEMBL9189260 0.83 FAAH (0.64) CES1CES2FAAHMEN1CYP1A2
SCHEMBL9191394 0.83 FAAH (0.64) CES1CES2FAAHMEN1CYP1A2
SCHEMBL9188084 0.83 FAAH (0.64) CES1CES2FAAHMEN1CYP1A2
SCHEMBL9192358 0.83 FAAH (0.64) CES1CES2FAAHMEN1CYP1A2
SCHEMBL9191895 0.83 FAAH (0.64) CES1CES2FAAHMEN1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0439185-B1 Liquid crystal compound SHOWA SHELL SEKIYU (JP) 1995-11-22 EP disclosed
US-5202054-A Exhibits three stable states of molecular orientation useful in displaying and electrooptics SHOWA SHELL SEKIYU K.K. (JP) 1993-04-13 US disclosed
EP-0439185-A2 Liquid crystal compound Showa Shell Sekiyu Kabushiki Kaisha (JP) 1991-07-31 EP disclosed