Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9500044 | 0.99 | HSD17B10 (0.43) | HSD17B10HTTLMNASMN1; SMN2TGM2 | |
| SCHEMBL9190225 | 0.94 | HTT (0.45) | HSD17B10HTTLMNASMN1; SMN2TGM2 | |
| SCHEMBL9192963 | 0.91 | HTT (0.46) | HSD17B10HTTLMNASMN1; SMN2TGM2 | |
| SCHEMBL9189651 | 0.87 | HTT (0.46) | HSD17B10HTTLMNASMN1; SMN2TGM2 | |
| SCHEMBL9193163 | 0.86 | HTT (0.43) | HSD17B10HTTLMNASMN1; SMN2TGM2 | |
| SCHEMBL9190696 | 0.86 | HTT (0.46) | HTTLMNASMN1; SMN2TGM2FOLH1 | |
| SCHEMBL7670412 | 0.84 | HTT (0.53) | HTTLMNASMN1; SMN2TGM2FOLH1 | |
| SCHEMBL9500031 | 0.83 | HTT (0.43) | HSD17B10HTTLMNASMN1; SMN2TGM2 | |
| SCHEMBL9187814 | 0.83 | FDPS (0.35) | HSD17B10TGM2 | |
| SCHEMBL8055648 | 0.82 | HTT (0.53) | HSD17B10HTTLMNASMN1; SMN2TGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0416689-B1 | Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors | MERCK & CO INC (US) | 1995-11-29 | — | — | EP | disclosed |
| US-5227506-A | Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors | MERCK & CO., INC. (US) | 1993-07-13 | — | — | US | disclosed |
| EP-0416689-A2 | Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors | MERCK & CO. INC. (US) | 1991-03-13 | — | — | EP | disclosed |