Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | GFER | P55789 | 2/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.49 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.48 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.48 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | RARB | P10826 | 1/20 | 0.48 |
| ▸ | COMT | P21964 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7369400 | 0.86 | TTR (0.67) | TTRALDH1A1MAPTLMNAHPGD | |
| SCHEMBL7371341 | 0.85 | TTR (0.65) | TTRALDH1A1MAPTLMNAHPGD | |
| SCHEMBL9184103 | 0.83 | TTR (0.64) | TTRALDH1A1MAPTLMNAHPGD | |
| SCHEMBL9185291 | 0.83 | TTR (0.57) | TTRALDH1A1MAPTLMNAHPGD | |
| SCHEMBL7373740 | 0.82 | TTR (0.71) | TTRALDH1A1MAPTLMNAHPGD | |
| SCHEMBL7368620 | 0.81 | TTR (0.64) | TTRALDH1A1MAPTLMNAHPGD | |
| SCHEMBL7365333 | 0.81 | TTR (0.75) | TTRALDH1A1MAPTLMNAHPGD | |
| SCHEMBL7365244 | 0.81 | TTR (0.60) | TTRALDH1A1MAPTLMNAHPGD | |
| SCHEMBL7373811 | 0.81 | TTR (0.74) | TTRALDH1A1MAPTLMNAHPGD | |
| SCHEMBL7369635 | 0.79 | TTR (0.58) | TTRALDH1A1MAPTLMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5476875-A | Catechol derivatives | HOFFMAN-LA ROCHE INC. (US) | 1995-12-19 | — | — | US | disclosed |