Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EED | O75530 | 2/20 | 0.62 |
| ▸ | GRIN2D | O15399 | 11/20 | 0.55 |
| ▸ | GRIN3B | O60391 | 11/20 | 0.55 |
| ▸ | GRIN1 | Q05586 | 11/20 | 0.55 |
| ▸ | GRIN2A | Q12879 | 11/20 | 0.55 |
| ▸ | GRIN2B | Q13224 | 11/20 | 0.55 |
| ▸ | GRIN2C | Q14957 | 11/20 | 0.55 |
| ▸ | GRIN3A | Q8TCU5 | 11/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.50 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6784527 | 0.88 | EED (0.62) | EEDGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL29979114 | 0.80 | GRIN2D (0.59) | EEDGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL23043587 | 0.80 | GRIN2D (0.59) | EEDGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL9193973 | 0.78 | ROCK1 (0.50) | EED | |
| SCHEMBL6441852 | 0.77 | EED (1.00) | EEDGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2767612 | 0.76 | MAPT (0.55) | EEDGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL29761207 | 0.76 | MAPT (0.50) | CYP3A4 | |
| SCHEMBL3592765 | 0.73 | MAPT (0.58) | EEDNUDT1CYP3A4 | |
| SCHEMBL9195257 | 0.73 | ROCK1 (0.52) | NUDT1 | |
| SCHEMBL16039371 | 0.72 | ADRA2C (0.58) | CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0428878-B1 | Benzocycloalkylaminopyridinamines and related compounds, a process and intermediates for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1995-06-07 | — | — | EP | claimed |
| EP-0428878-A2 | Benzocycloalkylaminopyridinamines and related compounds, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-05-29 | — | — | EP | claimed |
| US-4992448-A | Benzocycloalkylaminopyridinamines and related compounds as topical antiinflammatory agents for the treatment of skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-02-12 | — | — | US | claimed |
| EP-0428878-B1 | Benzocycloalkylaminopyridinamines and related compounds, a process and intermediates for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1995-06-07 | — | — | EP | disclosed |
| US-5037835-A | Benzocycloalkylaminopyridinamines and related compounds as topical antiinflammatory agents for the treatment of skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-08-06 | — | — | US | disclosed |
| EP-0428878-A2 | Benzocycloalkylaminopyridinamines and related compounds, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-05-29 | — | — | EP | disclosed |
| US-4992448-A | Benzocycloalkylaminopyridinamines and related compounds as topical antiinflammatory agents for the treatment of skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-02-12 | — | — | US | disclosed |