Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GBA1 | P04062 | 1/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5755963 | 0.79 | DDB1 (0.57) | POLBGBA1DDB1CRBNHSD11B1 | |
| SCHEMBL6727132 | 0.79 | POLB (0.45) | POLBGBA1DDB1CRBNHSD11B1 | |
| SCHEMBL6979837 | 0.78 | POLB (0.51) | POLBGBA1DDB1CRBNHSD11B1 | |
| Hydrochloric Acid SCHEMBL15650706 | 0.78 | DDB1 (0.55) | POLBGBA1DDB1CRBNHSD11B1 | |
| Hydrochloric Acid SCHEMBL6971865 | 0.77 | POLB (0.50) | POLBGBA1DDB1CRBNHSD11B1 | |
| SCHEMBL2729166 | 0.75 | DDB1 (0.55) | POLBGBA1DDB1CRBNHSD11B1 | |
| SCHEMBL25698327 | 0.70 | GBA1 (0.50) | POLBGBA1DDB1CRBN | |
| SCHEMBL4961020 | 0.69 | ALDH1A1 (0.50) | POLBDDB1CRBNNPC1ALDH1A1 | |
| SCHEMBL8676314 | 0.68 | DDB1 (0.51) | POLBGBA1DDB1CRBNHSD11B1 | |
| SCHEMBL19050135 | 0.68 | DDB1 (0.51) | POLBGBA1DDB1CRBNHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0655056-A1 | PIPERIDINYL-TERMINATED N-(DIHYDROXY ALKYL)-ETHYNYL-ALANINE AMIDES FOR TREATMENT OF HYPERTENSION | G.D. SEARLE & CO. (US) | 1995-05-31 | — | — | EP | claimed |
| WO-1994004495-A1 | PIPERIDINYL-TERMINATED N-(DIHYDROXY ALKYL)-ETHYNYL-ALANINE AMIDES FOR TREATMENT OF HYPERTENSION | G.D. SEARLE & CO. (US) | 1994-03-03 | — | — | WO | claimed |