Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | TOP2A | P11388 | 2/20 | 0.39 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9270289 | 0.86 | KMT2A (0.42) | KDM4EALDH1A1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL8006401 | 0.77 | CYP3A4 (0.55) | KDM4EALDH1A1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL2083786 | 0.69 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2MAPTTSHR | |
| SCHEMBL29559032 | 0.69 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2MAPTTSHR | |
| SCHEMBL21177044 | 0.69 | ATM (0.40) | KDM4EALDH1A1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL30702212 | 0.68 | MAPT (0.56) | KDM4EALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL3948845 | 0.68 | MAPT (0.56) | KDM4EALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL3141458 | 0.67 | ALDH1A1 (0.41) | KDM4EALDH1A1KMT2ACYP2C9MAPT | |
| SCHEMBL5264214 | 0.66 | MAPT (1.00) | KDM4EALDH1A1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL8209185 | 0.66 | KDM4E (0.74) | KDM4EALDH1A1KMT2ACYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0380038-B1 | 3-phenyl-5,6-dihydrobenz (C) - acridine-7-carboxylic acids and related compounds as cancer chemotherapeutic agents | DU PONT MERCK PHARMA (US) | 1995-06-28 | — | — | EP | disclosed |
| EP-0538392-A1 | 3-PHENYL-5,6-DIHYDROBENZ C]ACRIDINE-7-CARBOXYLIC ACIDS AND RELATED COMPOUNDS AS IMMUNOSUPPRESIVE AGENTS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-04-28 | — | — | EP | disclosed |
| US-5190753-A | 3-phenyl-5,6-dihydrobenziciacridine-7-carboxylic acids and related compounds as immunosuppressive agents | DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-03-02 | — | — | US | disclosed |
| US-5135934-A | 3-PHENYL-5,6-DIHYDROBENZ(C) ACRIDINE-7-CARBOXYLIC ACIDS AND RELATED COMPOUNDS AS IMMUNOSUPPRESSIVE AGENTS | DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-08-04 | — | — | US | disclosed |
| WO-1992000739-A1 | 3-PHENYL-5,6-DIHYDROBENZ[C]ACRIDINE-7-CARBOXYLIC ACIDS AND RELATED COMPOUNDS AS IMMUNOSUPPRESIVE AGENTS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-01-23 | — | — | WO | disclosed |
| EP-0380038-A3 | 3-PHENYL-5,6-DIHYDROBENZ (C) - ACRIDINE-7-CARBOXYLIC ACIDS AND RELATED COMPOUNDS AS CANCER CHEMOTHERAPEUTIC AGENTS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1991-11-13 | — | — | EP | disclosed |
| US-5002954-A | Leukemia, melanoma | DUPONT PHARMACEUTICALS COMPANY | 1991-03-26 | — | — | US | disclosed |
| US-5002954-A | Leukemia, melanoma | DUPONT PHARMACEUTICALS COMPANY | 1991-03-26 | — | — | US | disclosed |
| EP-0380038-A2 | 3-phenyl-5,6-dihydrobenz (C) - acridine-7-carboxylic acids and related compounds as cancer chemotherapeutic agents | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1990-08-01 | — | — | EP | disclosed |
| EP-0380038-A2 | 3-phenyl-5,6-dihydrobenz (C) - acridine-7-carboxylic acids and related compounds as cancer chemotherapeutic agents | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1990-08-01 | — | — | EP | disclosed |
| US-4918077-A | ANTITUMOR AGENTS | E. I. DU PONT DE NEMOURS & CO., INC. (US) | 1990-04-17 | — | — | US | disclosed |
| US-4918077-A | ANTITUMOR AGENTS | E. I. DU PONT DE NEMOURS & CO., INC. (US) | 1990-04-17 | — | — | US | disclosed |