Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.81 |
| ▸ | HTR2C | P28335 | 2/20 | 0.64 |
| ▸ | DRD2 | P14416 | 1/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.64 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 3/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30012078 | 0.78 | HTR2A (1.00) | HTR2AHTR2CDRD2SLC6A2SLC6A4 | |
| SCHEMBL5945674 | 0.78 | HTR2A (1.00) | HTR2AHTR2CDRD2SLC6A2SLC6A4 | |
| SCHEMBL4882972 | 0.77 | HTR2A (0.54) | HTR2AHTR2CDRD2SLC6A2SLC6A4 | |
| SCHEMBL31059131 | 0.77 | HTR2A (0.54) | HTR2AHTR2CDRD2SLC6A2SLC6A4 | |
| SCHEMBL1721596 | 0.77 | HTR2A (0.54) | HTR2AHTR2CDRD2SLC6A2SLC6A4 | |
| SCHEMBL7674578 | 0.77 | HTR2A (0.79) | HTR2AHTR2CDRD2SLC6A2SLC6A4 | |
| SCHEMBL27185199 | 0.74 | KDM1A (0.53) | HTR2AHTR2CDRD2KDM1AAKR1B1 | |
| SCHEMBL2311486 | 0.73 | HTR2A (0.77) | HTR2AHTR2CDRD2SLC6A2SLC6A4 | |
| SCHEMBL26686838 | 0.73 | HTR2A (0.61) | HTR2AHTR2CDRD2SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL1765279 | 0.72 | HTR2A (0.74) | HTR2AHTR2CDRD2SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0456183-B1 | Spiro dibenzosuberane derivatives | SHIONOGI & CO (JP) | 1995-10-04 | — | — | EP | claimed |
| EP-0456183-B1 | Spiro dibenzosuberane derivatives | SHIONOGI & CO (JP) | 1995-10-04 | — | — | EP | disclosed |