Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 4/20 | 0.52 |
| ▸ | ACHE | P22303 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
| ▸ | PRKAG1 | P54619 | 5/20 | 0.45 |
| ▸ | PRKAB1 | Q9Y478 | 5/20 | 0.45 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9197912 | 0.91 | HDAC3 (0.52) | BCHEACHEMAPTHDAC3HDAC4 | |
| SCHEMBL9195386 | 0.80 | CYP2D6 (0.48) | MAPTCCR2PRKAG1PRKAB1PRKAA2 | |
| SCHEMBL8786898 | 0.80 | BCHE (0.46) | BCHEACHEMAPTHDAC3HDAC4 | |
| SCHEMBL9258791 | 0.74 | HSD17B3 (0.56) | BCHEACHEMAPTTDP1L3MBTL1 | |
| SCHEMBL9337451 | 0.74 | MAPT (0.62) | MAPTPRKAG1PRKAB1PRKAA2HDAC3 | |
| SCHEMBL9276623 | 0.74 | ALDH1A1 (0.49) | BCHEACHEMAPTL3MBTL1CYP2D6 | |
| Hydrochloric Acid SCHEMBL9269838 | 0.73 | ALDH1A1 (0.48) | BCHEACHEMAPTL3MBTL1CYP2D6 | |
| SCHEMBL8786567 | 0.73 | MRGPRX4 (0.44) | BCHEACHEMAPTHDAC3HDAC4 | |
| SCHEMBL9193968 | 0.72 | EPHX2 (0.52) | ACHEPRKAG1PRKAB1PRKAA2HDAC2 | |
| SCHEMBL8886187 | 0.72 | HSD17B3 (0.56) | BCHEACHEMAPTL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0480641-B1 | Tricyclic heterocycles | ZENECA LTD (GB) | 1995-04-05 | — | — | EP | disclosed |
| US-5189033-A | Analgesics, antiiflammatory agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-02-23 | — | — | US | disclosed |
| EP-0480641-A1 | Tricyclic heterocycles | ZENECA LIMITED (GB) | 1992-04-15 | — | — | EP | disclosed |