Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.53 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | CDC42 | P60953 | 1/20 | 0.53 |
| ▸ | RAC1 | P63000 | 1/20 | 0.53 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9593388 | 1.00 | KDM4E (0.64) | KDM4ECYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL10521181 | 0.94 | KDM4E (0.57) | KDM4ECYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL16346363 | 0.88 | KDM4E (0.66) | KDM4ECYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL11217337 | 0.85 | KDM4E (0.62) | KDM4ECYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL9044944 | 0.85 | KDM4E (0.62) | KDM4ECYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL30824304 | 0.85 | KDM4E (0.62) | KDM4ECYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL3240836 | 0.85 | KDM4E (0.62) | KDM4ECYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL9046301 | 0.85 | KDM4E (0.62) | KDM4ECYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL9592745 | 0.85 | KDM4E (0.62) | KDM4ECYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL9529778 | 0.85 | KDM4E (0.62) | KDM4ECYP1A2ALDH1A1HPGDCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151702-B1 | ALPHA-HYDROXYKETONE ACETALS | SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) | 1987-11-25 | — | — | EP | claimed |
| EP-0433424-B1 | IMPROVED ASYMMETRIC CATALYTIC HYDROGENATION OF ALPHA-ARYLPROPENOIC ACIDS | MONSANTO CO (US) | 1995-05-24 | — | — | EP | disclosed |
| EP-0633238-A2 | Asymmetric catalytic hydrogenation of alpha-arylpropenoic acids | MONSANTO COMPANY (US) | 1995-01-11 | — | — | EP | disclosed |
| EP-0561908-A1 | METHOD FOR PREPARING $g(a)-ARYLPROPIONIC ACIDS | MONSANTO COMPANY (US) | 1993-09-29 | — | — | EP | disclosed |
| US-5233084-A | Electrochemical carboxylation; dehydration, catalytic asymetric hydrogenation | MONSANTO COMPANY (US) | 1993-08-03 | — | — | US | disclosed |
| US-5202474-A | Forming alpha-arylpropionic acid by using a coordination catalysts | MONSANTO COMPANY (US) | 1993-04-13 | — | — | US | disclosed |
| WO-1992009552-A1 | METHOD FOR PREPARING α-ARYLPROPIONIC ACIDS | MONSANTO COMPANY (US) | 1992-06-11 | — | — | WO | disclosed |
| EP-0433424-A1 | IMPROVED ASYMMETRIC CATALYTIC HYDROGENATION OF ALPHA-ARYLPROPENOIC ACIDS. | MONSANTO CO (US) | 1991-06-26 | — | — | EP | disclosed |
| US-4994607-A | Using a rhodium or ruthenium coordination complex of a chiral phosphine compound | MONSANTO COMPANY (US) | 1991-02-19 | — | — | US | disclosed |
| WO-1990015790-A1 | IMPROVED ASYMMETRIC CATALYTIC HYDROGENATION OF ALPHA-ARYLPROPENOIC ACIDS | MONSANTO COMPANY (US) | 1990-12-27 | — | — | WO | disclosed |
| EP-0048136-B1 | PROCESS FOR PREPARING ALPHA-AROMATIC GROUP SUBSTITUTED ALKANOIC ACIDS OR ESTERS THEREOF | SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) | 1986-06-11 | — | — | EP | disclosed |