Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | CDC42 | P60953 | 1/20 | 0.51 |
| ▸ | RAC1 | P63000 | 1/20 | 0.51 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PLAU | P00749 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9044944 | 1.00 | KDM4E (0.62) | KDM4ECYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL9592161 | 1.00 | KDM4E (0.62) | KDM4ECYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL16346363 | 0.86 | KDM4E (0.66) | KDM4ECYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL10415359 | 0.85 | ALDH1A1 (0.49) | KDM4ECYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL9593388 | 0.85 | KDM4E (0.64) | KDM4ECYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL9196872 | 0.85 | KDM4E (0.64) | KDM4ECYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL585274 | 0.84 | ALDH1A1 (0.66) | CYP1A2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL10710104 | 0.84 | ALDH1A1 (0.48) | KDM4ECYP1A2ALDH1A1HSD17B10CYP2C9 | |
| SCHEMBL9046301 | 0.83 | KDM4E (0.62) | KDM4ECYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL9592745 | 0.83 | KDM4E (0.62) | KDM4ECYP1A2ALDH1A1HPGDCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2262533-A | — | — | None | — | — | JP | disclosed |
| EP-0273316-B1 | STEREOCONVERGENT PROCESS FOR PREPARING OPTICALLY ACTIVE CARBOXYLIC ACIDS | ZAMBON S.p.A. (IT) | 1993-07-28 | — | — | EP | disclosed |
| US-5210258-A | Optically active alpha-naththylalkyl ketones | SYNTEX PHARMACEUTICALS INTERNATIONAL LTD. (BM) | 1993-05-11 | — | — | US | disclosed |
| US-5084569-A | TRIOXY BICYCLIC COMPOUNDS USEFUL FOR PREPARING OPTICALLY ACTIVE CARBOXYLIC ACIDS | ZAMBON SPA (IT) | 1992-01-28 | — | — | US | disclosed |
| JP-H02262533-A | OPTICALLY ACTIVE KETONE | SYNTEX PHARMCEUT INTERNATL LTD | 1990-10-25 | — | — | JP | disclosed |
| US-4922009-A | Stereoconvergent process for preparing optically active carboxylic acids | ZAMBON SPA (IT) | 1990-05-01 | — | — | US | disclosed |
| US-4912254-A | Preparation of α-arylalkanoic acids | SYNTEX PHARMACEUTICAL INTERNATIONAL LIMITED (BM) | 1990-03-27 | — | — | US | disclosed |
| EP-0081993-B1 | OPTICALLY ACTIVE ALPHA-SUBSTITUTED ARYL KETONES, THEIR PREPARATION AND THEIR USE IN PREPARING ALPHA-ARYLALKANOIC ACIDS | SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) | 1988-08-17 | — | — | EP | disclosed |
| EP-0273316-A2 | Stereoconvergent process for preparing optically active carboxylic acids | ZAMBON S.p.A. (IT) | 1988-07-06 | — | — | EP | disclosed |
| US-4749804-A | Preparation of stereoisomers of ketals | SYNTEX (U.S.A.) INC. (US) | 1988-06-07 | — | — | US | disclosed |
| US-4605758-A | Preparation of α-arylalkanoic acids | SYNTEX PHARMACEUTICALS INTERNATIONAL LTD. (BM) | 1986-08-12 | — | — | US | disclosed |
| EP-0081993-A2 | Optically active alpha-substituted aryl ketones, their preparation and their use in preparing alpha-arylalkanoic acids | SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) | 1983-06-22 | — | — | EP | disclosed |