Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.59 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.59 |
| ▸ | PARP11 | Q9NR21 | 5/20 | 0.54 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.54 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7588431 | 0.86 | PARP10 (0.56) | PARP1TRPM2PARP11PARP10HDAC1 | |
| SCHEMBL7582536 | 0.82 | PARP1 (0.62) | PARP1TRPM2PARP11PARP10HDAC1 | |
| SCHEMBL9196870 | 0.82 | PARP1 (0.66) | PARP1TRPM2PARP11PARP10HDAC1 | |
| SCHEMBL4717294 | 0.81 | PARP1 (0.65) | PARP1TRPM2PARP11PARP10HDAC1 | |
| SCHEMBL7586205 | 0.81 | PARP1 (0.65) | PARP1TRPM2PARP11PARP10HDAC1 | |
| SCHEMBL28350032 | 0.81 | MRGPRX4 (0.50) | S1PR5IDO1HPGDMAOAMAOB | |
| SCHEMBL9193581 | 0.79 | PARP1 (0.48) | PARP1TRPM2PARP11PARP10HDAC1 | |
| SCHEMBL7581574 | 0.79 | PARP1 (0.58) | PARP1TRPM2PARP11PARP10HDAC1 | |
| SCHEMBL10576365 | 0.79 | PARP1 (0.65) | PARP1TRPM2PARP11PARP10HPGD | |
| SCHEMBL15105870 | 0.77 | TDP1 (0.53) | PARP1TRPM2PARP11PARP10HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0355750-B1 | Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process | WARNER LAMBERT CO (US) | 1995-01-25 | — | — | EP | claimed |
| US-5177075-A | Antitumor agents | WARNER-LAMBERT COMPANY (US) | 1993-01-05 | — | — | US | claimed |
| EP-0355750-B1 | Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process | WARNER LAMBERT CO (US) | 1995-01-25 | — | — | EP | disclosed |
| US-5177075-A | Antitumor agents | WARNER-LAMBERT COMPANY (US) | 1993-01-05 | — | — | US | disclosed |
| EP-0355750-A1 | Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process | WARNER-LAMBERT COMPANY (US) | 1990-02-28 | — | — | EP | disclosed |