Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 11/20 | 0.66 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.66 |
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.51 |
| ▸ | PARP11 | Q9NR21 | 5/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7586205 | 0.87 | PARP1 (0.65) | PARP1TRPM2PARP10PARP11MRGPRX4 | |
| SCHEMBL7582536 | 0.86 | PARP1 (0.62) | PARP1TRPM2PARP10PARP11MRGPRX4 | |
| SCHEMBL4717294 | 0.84 | PARP1 (0.65) | PARP1TRPM2PARP10PARP11MRGPRX4 | |
| SCHEMBL7581574 | 0.82 | PARP1 (0.58) | PARP1TRPM2PARP10PARP11MRGPRX4 | |
| SCHEMBL9196993 | 0.82 | PARP1 (0.59) | PARP1TRPM2PARP10PARP11HDAC1 | |
| SCHEMBL10576365 | 0.82 | PARP1 (0.65) | PARP1TRPM2PARP10PARP11 | |
| SCHEMBL7587804 | 0.81 | TRPM2 (0.93) | PARP1TRPM2 | |
| SCHEMBL29478301 | 0.80 | TRPM2 (1.00) | PARP1TRPM2 | |
| SCHEMBL28726010 | 0.80 | PARP1 (0.59) | PARP1TRPM2PARP10PARP11MRGPRX4 | |
| SCHEMBL214027 | 0.80 | TRPM2 (1.00) | PARP1TRPM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0355750-B1 | Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process | WARNER LAMBERT CO (US) | 1995-01-25 | — | — | EP | disclosed |
| US-5177075-A | Antitumor agents | WARNER-LAMBERT COMPANY (US) | 1993-01-05 | — | — | US | disclosed |
| EP-0355750-A1 | Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process | WARNER-LAMBERT COMPANY (US) | 1990-02-28 | — | — | EP | disclosed |