Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.47 |
| ▸ | CYP17A1 | P05093 | 4/20 | 0.47 |
| ▸ | CYP26A1 | O43174 | 6/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.40 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.40 |
| ▸ | FNTA | P49354 | 1/20 | 0.37 |
| ▸ | FNTB | P49356 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9198062 | 0.91 | CYP11B1 (0.47) | CYP11B1CYP11B2CYP17A1CYP26A1CYP3A4 | |
| SCHEMBL9728123 | 0.80 | CYP17A1 (0.45) | CYP11B1CYP11B2CYP17A1CYP26A1CYP3A4 | |
| SCHEMBL27352418 | 0.79 | CYP11B1 (0.47) | CYP11B1CYP11B2CYP17A1CYP26A1CYP3A4 | |
| SCHEMBL9192257 | 0.78 | KDM4E (0.44) | CYP11B1CYP11B2CYP17A1CYP26A1CYP3A4 | |
| SCHEMBL9192629 | 0.77 | CYP17A1 (0.43) | CYP11B1CYP11B2CYP17A1CYP26A1CYP3A4 | |
| SCHEMBL27352420 | 0.77 | CYP11B1 (0.47) | CYP11B1CYP11B2CYP17A1CYP26A1CYP3A4 | |
| SCHEMBL9190861 | 0.76 | CYP17A1 (0.56) | CYP11B1CYP11B2CYP17A1CYP26A1CYP3A4 | |
| SCHEMBL9191072 | 0.76 | CYP17A1 (0.42) | CYP11B1CYP11B2CYP17A1CYP26A1CYP3A4 | |
| SCHEMBL9190836 | 0.76 | CYP17A1 (0.57) | CYP11B1CYP11B2CYP17A1CYP26A1CYP3A4 | |
| SCHEMBL31526691 | 0.75 | MAPKAPK2 (0.46) | CYP3A4CYP2C8CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0371564-B1 | (1H-azol-1-ylmethyl)substituted quinoline, quinazoline or quinoxaline derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1995-07-12 | — | — | EP | disclosed |
| US-5151421-A | Compounds for inhibition of metabolism of retinoids, for treatment for proliferation of epithelial cells and keratin disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-29 | — | — | US | disclosed |
| US-5028606-A | Retinoid metabolism inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-07-02 | — | — | US | disclosed |
| EP-0371564-A2 | (1H-azol-1-ylmethyl)substituted quinoline, quinazoline or quinoxaline derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-06-06 | — | — | EP | disclosed |