Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | BLM | P54132 | 2/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CA5A | P35218 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | LDHA | P00338 | 2/20 | 0.40 |
| ▸ | LDHB | P07195 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrogen Peroxide SCHEMBL4232421 | 0.96 | — | — | |
| Carbamic Acid SCHEMBL6289381 | 0.92 | ACHE (0.58) | CRBNLMNATSHRNFKB1CA2 | |
| SCHEMBL27939070 | 0.91 | CRBN (0.60) | CRBNLMNATSHRNFKB1CA2 | |
| SCHEMBL27524722 | 0.91 | CRBN (0.60) | CRBNLMNATSHRNFKB1CA2 | |
| SCHEMBL15045 | 0.91 | — | — | |
| SCHEMBL27560286 | 0.91 | CRBN (0.60) | CRBNLMNATSHRNFKB1CA2 | |
| Benzene SCHEMBL27729594 | 0.88 | CRBN (0.50) | CRBNLMNATSHRNFKB1CA2 | |
| Hydrochloric Acid SCHEMBL5583405 | 0.87 | — | — | |
| SCHEMBL978129 | 0.87 | — | — | |
| Ammonia Solution, Strong SCHEMBL9487082 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1878646-B | Production of the inner lining of a vehicle | FAURECIA INNENRAUM SYS GMBH | 2010-12-15 | — | — | CN | claimed |
| CN-1878646-A | Production of the inner lining of a vehicle | FAURECIA INNENRAUM SYS GMBH (DE) | 2006-12-13 | — | — | CN | claimed |
| CN-104231254-B | For the method producing polycarbonate compositions | 沙特基础全球技术有限公司 | 2016-06-29 | — | — | CN | disclosed |
| CN-1124458-A | Water repellent orthopedic dressing | MINNESOTA MINING & MFG (US) | 1996-06-12 | — | — | CN | disclosed |
| US-5399325-A | Complexing ammonium carbonate, bicarbonate and carbamate; air pollution control; by-product inhibition | NALCO FUEL TECH (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0495089-A4 | NITROGEN OXIDES REDUCTION USING A UREA HYDROLYSATE | NALCO FUEL TECH (US) | 1993-03-10 | — | — | EP | disclosed |
| EP-0495089-A1 | NITROGEN OXIDES REDUCTION USING A UREA HYDROLYSATE. | NALCO FUEL TECH (US) | 1992-07-22 | — | — | EP | disclosed |
| WO-1992002450-A1 | NITROGEN OXIDES REDUCTION USING A UREA HYDROLYSATE | NALCO FUEL TECH (US) | 1992-02-20 | — | — | WO | disclosed |