Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 10/20 | 0.51 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9199400 | 1.00 | CYP19A1 (0.51) | CYP19A1CYP26A1CYP11B1CYP11B2CYP17A1 | |
| SCHEMBL9195007 | 0.88 | CYP17A1 (0.52) | CYP19A1CYP26A1CYP17A1 | |
| SCHEMBL9196055 | 0.88 | CYP19A1 (0.52) | CYP19A1CYP26A1CYP17A1 | |
| SCHEMBL9198411 | 0.88 | CYP19A1 (0.52) | CYP19A1CYP26A1CYP17A1 | |
| SCHEMBL11200007 | 0.82 | CYP26A1 (0.43) | CYP19A1CYP26A1CYP11B1CYP11B2CYP17A1 | |
| SCHEMBL11073123 | 0.71 | CYP11B1 (0.47) | CYP19A1CYP11B1CYP11B2TDP1 | |
| SCHEMBL11097133 | 0.70 | CYP19A1 (0.44) | CYP19A1CYP11B1CYP11B2CYP24A1 | |
| SCHEMBL11196176 | 0.70 | CYP26A1 (0.49) | CYP19A1CYP26A1CYP11B1CYP11B2CYP17A1 | |
| SCHEMBL22749261 | 0.69 | CYP17A1 (0.45) | CYP19A1CYP26A1CYP11B1CYP11B2CYP17A1 | |
| SCHEMBL9134256 | 0.69 | CYP17A1 (0.45) | CYP19A1CYP26A1CYP11B1CYP11B2CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0354539-B1 | Antiinflammatory carbinoloimidazoles | DU PONT MERCK PHARMA (US) | 1995-04-05 | — | — | EP | disclosed |
| US-4859693-A | Antiinflammatory carbinoloimidazoles | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-08-22 | — | — | US | disclosed |