Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 8/20 | 0.59 |
| ▸ | CYSLTR1 | Q9Y271 | 8/20 | 0.59 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.59 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | GMNN | O75496 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9208722 | 0.91 | CYSLTR1 (0.60) | GPBAR1CYSLTR1CYSLTR2PDE10ACYP1A2 | |
| SCHEMBL9530803 | 0.87 | PDE10A (0.52) | GPBAR1CYSLTR1CYSLTR2PDE10ACYP1A2 | |
| SCHEMBL9529814 | 0.87 | CYSLTR1 (0.52) | GPBAR1CYSLTR1CYSLTR2PDE10ACYP1A2 | |
| SCHEMBL9529563 | 0.85 | CYSLTR1 (0.63) | GPBAR1CYSLTR1CYSLTR2ALOX5FFAR1 | |
| SCHEMBL9530848 | 0.82 | CYSLTR1 (0.59) | GPBAR1CYSLTR1CYSLTR2PDE10AALOX5 | |
| SCHEMBL9531945 | 0.81 | PDE10A (0.51) | GPBAR1CYSLTR1CYSLTR2PDE10ACYP1A2 | |
| SCHEMBL9529663 | 0.81 | PDE10A (0.51) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL9530340 | 0.80 | CYSLTR1 (0.55) | GPBAR1CYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL2108367 | 0.80 | ALOX5AP (0.57) | — | |
| SCHEMBL9201587 | 0.79 | CYSLTR1 (0.56) | GPBAR1CYSLTR1CYSLTR2PDE10ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544821-B1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS | PFIZER (US) | 1995-01-11 | — | — | EP | claimed |
| EP-0544821-B1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS | PFIZER (US) | 1995-01-11 | — | — | EP | disclosed |