Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 7/20 | 0.63 |
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.63 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | PPARD | Q03181 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.48 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.47 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9530848 | 0.90 | CYSLTR1 (0.59) | CYSLTR1CYSLTR2FFAR1AKR1B1ALOX5 | |
| SCHEMBL9199458 | 0.85 | GPBAR1 (0.59) | CYSLTR1CYSLTR2FFAR1AKR1B1ALOX5 | |
| SCHEMBL9532326 | 0.83 | ALDH1A1 (0.58) | PPARGPPARDPPARA | |
| SCHEMBL9208722 | 0.81 | CYSLTR1 (0.60) | CYSLTR1CYSLTR2ALOX5GPBAR1 | |
| SCHEMBL9529814 | 0.81 | CYSLTR1 (0.52) | CYSLTR1CYSLTR2FFAR1AKR1B1GPBAR1 | |
| SCHEMBL9209068 | 0.80 | CYSLTR1 (0.53) | CYSLTR1CYSLTR2ALOX5GPBAR1 | |
| SCHEMBL9530803 | 0.79 | PDE10A (0.52) | CYSLTR1CYSLTR2FFAR1AKR1B1GPBAR1 | |
| SCHEMBL2108367 | 0.79 | ALOX5AP (0.57) | ALOX5AP | |
| SCHEMBL14021499 | 0.78 | CYSLTR1 (1.00) | CYSLTR1CYSLTR2FFAR1AKR1B1ALOX5 | |
| SCHEMBL9211036 | 0.77 | CYSLTR1 (0.52) | CYSLTR1ALOX5GPBAR1ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544821-A1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS. | PFIZER (US) | 1993-06-09 | — | — | EP | disclosed |
| WO-1992006088-A1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1992-04-16 | — | — | WO | disclosed |