Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.72 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.69 |
| ▸ | TNKS | O95271 | 1/20 | 0.65 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13592819 | 0.89 | CYP19A1 (0.68) | SIGMAR1ABCG2TNKSCYP19A1MEN1 | |
| SCHEMBL7933564 | 0.88 | SIGMAR1 (0.73) | SIGMAR1ABCG2TNKSCYP19A1MEN1 | |
| SCHEMBL10025659 | 0.87 | SIGMAR1 (0.76) | SIGMAR1ABCG2TNKSCYP19A1MEN1 | |
| SCHEMBL9391105 | 0.87 | SIGMAR1 (0.72) | SIGMAR1ABCG2TNKSCYP19A1MEN1 | |
| SCHEMBL7372368 | 0.87 | SIGMAR1 (0.72) | SIGMAR1ABCG2TNKSCYP19A1 | |
| SCHEMBL4406405 | 0.86 | SIGMAR1 (0.55) | SIGMAR1ABCG2MAPT | |
| SCHEMBL12941167 | 0.85 | SIGMAR1 (0.82) | SIGMAR1ABCG2TNKSCYP19A1 | |
| SCHEMBL12940261 | 0.84 | CYP19A1 (0.68) | SIGMAR1ABCG2TNKSCYP19A1MEN1 | |
| SCHEMBL9140701 | 0.84 | KDM4E (0.74) | SIGMAR1ABCG2TNKSCYP19A1MEN1 | |
| SCHEMBL4410884 | 0.83 | CYP1A1 (0.54) | SIGMAR1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0430693-B1 | Pyrimidinedione derivative compounds, method for preparing same, and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS (JP) | 1995-05-31 | — | — | EP | disclosed |
| US-5114941-A | PYRIMIDINEDIONE DERIVATIVE COMPOUNDS, METHOD FOR PREPARING SAME, AND ANTIARRYTHMIC AGENTS CONTAINING SAME | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1992-05-19 | — | — | US | disclosed |
| EP-0430693-A2 | Pyrimidinedione derivative compounds, method for preparing same, and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1991-06-05 | — | — | EP | disclosed |