Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | ALPI | P09923 | 1/20 | 0.47 |
| ▸ | ALPG | P10696 | 1/20 | 0.47 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.47 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11231448 | 0.87 | SMN1; SMN2 (0.55) | NPC1ALDH1A1KMT2ALMNAHPGD | |
| SCHEMBL11839536 | 0.82 | NPC1 (0.62) | NPC1KMT2ALMNAMEN1GAA | |
| SCHEMBL5644953 | 0.76 | NPC1 (0.88) | NPC1ALDH1A1KMT2ALMNAMEN1 | |
| SCHEMBL28049266 | 0.76 | NPC1 (0.58) | NPC1ALDH1A1KMT2ALMNAMEN1 | |
| SCHEMBL27244976 | 0.75 | POLB (0.54) | ALDH1A1KMT2ALMNAHPGDMEN1 | |
| SCHEMBL5623571 | 0.75 | POLB (0.54) | ALDH1A1KMT2ALMNAHPGDMEN1 | |
| SCHEMBL13494840 | 0.75 | NPC1 (0.74) | NPC1ALDH1A1KMT2ALMNAHPGD | |
| SCHEMBL26763424 | 0.75 | MLYCD (0.65) | NPC1ALDH1A1KMT2ALMNAHPGD | |
| SCHEMBL2185023 | 0.75 | MLYCD (0.65) | NPC1ALDH1A1KMT2ALMNAHPGD | |
| Phenol SCHEMBL8488546 | 0.74 | NPC1 (0.63) | NPC1ALDH1A1KMT2ALMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0624159-A4 | PYRIDYL SUBSTITUTED IMIDAZOLES. | SMITHKLINE BEECHAM CORP (US) | 1995-04-12 | — | — | EP | disclosed |
| EP-0624159-A1 | PYRIDYL SUBSTITUTED IMIDAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 1994-11-17 | — | — | EP | disclosed |
| WO-1993014082-A1 | PYRIDYL SUBSTITUTED IMIDAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-07-22 | — | — | WO | disclosed |