Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SCN1A | P35498 | 3/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9207734 | 0.86 | KCNN4 (0.36) | CYP2C19LMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4670349 | 0.79 | CYP2C19 (0.37) | CYP2C19LMNASCN1ASCN2ASCN3A | |
| SCHEMBL4669945 | 0.77 | MAPK1 (0.36) | CYP2C19LMNASCN1ASCN2ASCN3A | |
| SCHEMBL28723552 | 0.76 | CYP2C19 (0.42) | CYP2C19LMNASCN1ASCN2ASCN3A | |
| SCHEMBL4671959 | 0.76 | LMNA (0.35) | CYP2C19LMNASCN1ASCN2ASCN3A | |
| SCHEMBL9210109 | 0.76 | CYP2C19 (0.44) | CYP2C19CYP1A2CYP3A4CYP2C9ALDH1A1 | |
| SCHEMBL26612287 | 0.72 | LMNA (0.38) | CYP2C19LMNASCN1ASCN2ASCN3A | |
| SCHEMBL905247 | 0.71 | KCNN4 (0.38) | CYP2C19CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL519210 | 0.71 | KCNN4 (0.38) | CYP2C19CYP1A2CYP2D6CYP2C9ALDH1A1 | |
| SCHEMBL895242 | 0.71 | KCNN4 (0.36) | CYP2C19LMNAALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5475008-A | Selective non-competitive antagonists of n-methyl-d-aspartate receptors | MERCK SHARP & DOHME LIMITED (GB) | 1995-12-12 | — | — | US | disclosed |
| EP-0459561-B1 | Dioxo-tetrahydroquinoline derivatives | MERCK SHARP & DOHME (GB) | 1995-09-20 | — | — | EP | disclosed |
| EP-0614363-A1 | QUINOLONE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1994-09-14 | — | — | EP | disclosed |
| US-5268378-A | Oxo group in 2 and 4 position | MERCK SHARP & DOHME, LIMITED (GB) | 1993-12-07 | — | — | US | disclosed |
| WO-1993010783-A2 | QUINOLONE DERIVATIVES AND THEIR USE AS AMPA AND NMDA RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1993-06-10 | — | — | WO | disclosed |
| EP-0459561-A2 | Dioxo-tetrahydroquinoline derivatives | MERCK SHARP & DOHME LTD. (GB) | 1991-12-04 | — | — | EP | disclosed |