Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | HEXA | P06865 | 1/20 | 0.41 |
| ▸ | HEXB | P07686 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.41 |
| ▸ | TUBB | P07437 | 2/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5775254 | 0.85 | MEN1 (0.56) | MEN1KMT2ACYP19A1CYP2C9CYP2C19 | |
| SCHEMBL5774360 | 0.81 | LMNA (0.57) | MEN1KMT2AKDM4EGAALMNA | |
| SCHEMBL5772652 | 0.80 | MEN1 (0.52) | MEN1KMT2ACYP19A1CYP2C9CYP2C19 | |
| SCHEMBL5776975 | 0.80 | KMT2A (0.49) | MEN1KMT2AKDM4EGAALMNA | |
| SCHEMBL9200948 | 0.79 | MEN1 (0.47) | MEN1KMT2ACYP19A1CYP2C9CYP2C19 | |
| SCHEMBL1167880 | 0.78 | KMT2A (0.66) | MEN1KMT2ACYP19A1CYP2C9CYP2C19 | |
| SCHEMBL1167690 | 0.77 | KMT2A (1.00) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL30078294 | 0.77 | KMT2A (1.00) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL5651574 | 0.76 | MEN1 (0.82) | MEN1KMT2ACYP19A1CYP2C9CYP2C19 | |
| SCHEMBL20507215 | 0.76 | MEN1 (0.48) | MEN1KMT2ACYP19A1CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0435381-B1 | Antipicornaviral pyridazinamines | JANSSEN PHARMACEUTICA NV (BE) | 1995-11-02 | — | — | EP | disclosed |
| US-5196535-A | Viricides | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-23 | — | — | US | disclosed |
| US-5100893-A | Viricides, effective against picorna virus, durability | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-03-31 | — | — | US | disclosed |
| EP-0435381-A1 | Antipicornaviral pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-07-03 | — | — | EP | disclosed |