Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 9/20 | 0.61 |
| ▸ | GABRB2 | P47870 | 9/20 | 0.61 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.57 |
| ▸ | CNR2 | P34972 | 4/20 | 0.57 |
| ▸ | CNR1 | P21554 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.57 |
| ▸ | RXRA | P19793 | 1/20 | 0.57 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.57 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.57 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.57 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.57 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.56 |
| ▸ | XDH | P47989 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15376929 | 0.86 | GABRA1 (0.58) | GABRA1GABRB2ALOX5CNR2CNR1 | |
| SCHEMBL9271749 | 0.85 | GABRA1 (0.56) | GABRA1GABRB2ALOX5CNR2CNR1 | |
| SCHEMBL11037594 | 0.83 | GABRA1 (0.58) | GABRA1GABRB2ALOX5CNR2CNR1 | |
| SCHEMBL15377159 | 0.82 | GABRA1 (0.52) | GABRA1GABRB2ALOX5CNR2CNR1 | |
| SCHEMBL29443445 | 0.82 | GABRA1 (0.76) | GABRA1GABRB2ALOX5CNR2CNR1 | |
| SCHEMBL7785437 | 0.82 | GABRA1 (0.76) | GABRA1GABRB2ALOX5CNR2CNR1 | |
| SCHEMBL9201904 | 0.80 | GABRA1 (0.60) | GABRA1GABRB2ALOX5CNR2CNR1 | |
| SCHEMBL7785448 | 0.79 | GABRA1 (0.76) | GABRA1GABRB2ALOX5CNR2CNR1 | |
| SCHEMBL11891611 | 0.78 | GABRA1 (0.46) | GABRA1GABRB2ALOX5CNR2CNR1 | |
| SCHEMBL252293 | 0.78 | GABRA1 (1.00) | GABRA1GABRB2ALOX5CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0382213-B1 | Biphenyl derivative, nerve cell degeneration repairing or protecting agent and process for preparing a phenyl derivative contained in the agent | OTSUKA PHARMA CO LTD (JP) | 1995-05-10 | — | — | EP | disclosed |
| US-5053548-A | Containing hydroxy substituents; nervous system disorders | OTSUKA PHARMACEUTICAL COMPANY, LTD. (JP) | 1991-10-01 | — | — | US | disclosed |
| EP-0382213-A2 | Biphenyl derivative, nerve cell degeneration repairing or protecting agent and process for preparing a phenyl derivative contained in the agent | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-08-16 | — | — | EP | disclosed |