Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPA1 | P27694 | 6/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | PPP1CA | P62136 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | MDM2 | Q00987 | 6/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 6/20 | 0.52 |
| ▸ | BCL2 | P10415 | 5/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9209855 | 0.89 | PTGS1 (0.46) | RPA1SMN1; SMN2L3MBTL1PPP1CAMEN1 | |
| SCHEMBL9204760 | 0.86 | KMT2A (0.72) | RPA1SMN1; SMN2L3MBTL1PPP1CAMEN1 | |
| SCHEMBL9204658 | 0.86 | KMT2A (0.72) | RPA1SMN1; SMN2L3MBTL1PPP1CAMEN1 | |
| SCHEMBL7463244 | 0.84 | RPA1 (0.76) | RPA1SMN1; SMN2L3MBTL1PPP1CAMDM2 | |
| SCHEMBL8641975 | 0.83 | RPA1 (0.67) | RPA1SMN1; SMN2L3MBTL1PPP1CAMEN1 | |
| Hydrochloric Acid SCHEMBL9209971 | 0.83 | CA9 (0.56) | MEN1KMT2AMDM2MCL1BCL2 | |
| SCHEMBL8638380 | 0.82 | RPA1 (0.55) | RPA1SMN1; SMN2L3MBTL1PPP1CAMEN1 | |
| SCHEMBL9208255 | 0.81 | RPA1 (0.57) | RPA1SMN1; SMN2L3MBTL1PPP1CAMEN1 | |
| SCHEMBL1987609 | 0.81 | RPA1 (0.82) | RPA1SMN1; SMN2L3MBTL1PPP1CAMEN1 | |
| SCHEMBL3876516 | 0.78 | RPA1 (0.56) | RPA1SMN1; SMN2L3MBTL1PPP1CAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |