Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPA1 | P27694 | 7/20 | 0.76 |
| ▸ | MARS1 | P56192 | 1/20 | 0.65 |
| ▸ | MDM2 | Q00987 | 7/20 | 0.58 |
| ▸ | MCL1 | Q07820 | 6/20 | 0.58 |
| ▸ | BCL2 | P10415 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.57 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.55 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9056282 | 0.91 | RPA1 (0.90) | RPA1MARS1MDM2MCL1BCL2 | |
| SCHEMBL3863714 | 0.89 | RPA1 (0.60) | RPA1MARS1MDM2MCL1BCL2 | |
| SCHEMBL3139245 | 0.86 | RPA1 (1.00) | RPA1MARS1MDM2MCL1BCL2 | |
| SCHEMBL7467365 | 0.85 | CA9 (0.58) | RPA1MARS1MDM2MCL1BCL2 | |
| SCHEMBL9204658 | 0.85 | KMT2A (0.72) | RPA1MARS1MDM2MCL1BCL2 | |
| SCHEMBL9204760 | 0.85 | KMT2A (0.72) | RPA1MARS1MDM2MCL1BCL2 | |
| SCHEMBL9201599 | 0.84 | RPA1 (0.58) | RPA1MDM2MCL1BCL2SMN1; SMN2 | |
| SCHEMBL8199732 | 0.83 | RPA1 (0.65) | RPA1MARS1SMN1; SMN2PPP1CAL3MBTL1 | |
| SCHEMBL8641975 | 0.82 | RPA1 (0.67) | RPA1MDM2MCL1BCL2SMN1; SMN2 | |
| SCHEMBL32690380 | 0.82 | RPA1 (0.74) | RPA1MARS1MDM2MCL1BCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0554829-B1 | Pyrazole derivatives with antiinflammatory, analgesic and antithrombolic activity | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-05-15 | — | — | EP | disclosed |
| US-5670533-A | ANTIINFLAMMATORY AGENTS, ANALGESICS OR ANTIRHEUMATIC DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-23 | — | — | US | disclosed |
| US-5550147-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTITHROMBOTIC AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-08-27 | — | — | US | disclosed |
| EP-0554829-A2 | Pyrazole derivatives with antiinflammatory, analgesic and antithrombolic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-08-11 | — | — | EP | disclosed |