Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 0.67 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.65 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.64 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9208534 | 0.92 | PTGS2 (0.65) | PTGS2CHRNA7MALT1AOC3PTGS1 | |
| SCHEMBL9210924 | 0.84 | AOC3 (0.70) | PTGS2CHRNA7AOC3PTGS1 | |
| SCHEMBL9203245 | 0.84 | MEN1 (0.70) | PTGS2CHRNA7AOC3PTGS1 | |
| SCHEMBL27524813 | 0.84 | AOC3 (0.61) | PTGS2CHRNA7AOC3PTGS1 | |
| SCHEMBL9201596 | 0.84 | MALT1 (0.65) | PTGS2CHRNA7MALT1 | |
| SCHEMBL16640301 | 0.83 | MALT1 (0.67) | PTGS2CHRNA7MALT1PTGS1 | |
| SCHEMBL9199556 | 0.83 | AOC3 (0.65) | PTGS2CHRNA7AOC3PTGS1 | |
| SCHEMBL9204761 | 0.83 | AOC3 (0.65) | PTGS2CHRNA7AOC3PTGS1 | |
| SCHEMBL9055103 | 0.82 | AOC3 (0.64) | PTGS2CHRNA7AOC3PTGS1 | |
| SCHEMBL16640303 | 0.82 | MALT1 (0.65) | PTGS2CHRNA7MALT1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1046506-C | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-11-17 | — | — | CN | disclosed |
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |