SCHEMBL9201706

SCHEMBL9201706

COc1ccc(CC(N)c2ccc(Cl)cc2)cc1

nearest known ligand 0.83

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.83
CYP2D6 P10635 1/20 0.83
CYP2C19 P33261 1/20 0.83
SLC6A4 P31645 2/20 0.56
TDP1 Q9NUW8 1/20 0.51
CNR2 P34972 1/20 0.51
SLC6A2 P23975 1/20 0.50
SLC6A3 Q01959 1/20 0.50
FPR2 P25090 1/20 0.47
SCN4A P35499 2/20 0.45
KMT2A Q03164 1/20 0.45
LDHA P00338 1/20 0.45
GAA P10253 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8056897 1.00 CYP1A2 (0.83) CYP1A2CYP2D6CYP2C19SLC6A4TDP1
SCHEMBL9564556 0.91 CYP1A2 (1.00) CYP1A2CYP2D6CYP2C19SLC6A4LDHA
SCHEMBL12706131 0.91 CYP1A2 (1.00) CYP1A2CYP2D6CYP2C19SLC6A4LDHA
SCHEMBL3734984 0.84 CYP1A2 (0.58) CYP1A2CYP2D6CYP2C19SLC6A4TDP1
SCHEMBL3734743 0.84 CYP1A2 (0.58) CYP1A2CYP2D6CYP2C19SLC6A4TDP1
SCHEMBL8066335 0.83 CYP1A2 (0.83) CYP1A2CYP2D6CYP2C19SLC6A4KMT2A
SCHEMBL7039221 0.83 CYP1A2 (0.83) CYP1A2CYP2D6CYP2C19SLC6A4CNR2
SCHEMBL2368100 0.83 CYP1A2 (0.83) CYP1A2CYP2D6CYP2C19SLC6A4CNR2
SCHEMBL5680007 0.83 CYP1A2 (0.83) CYP1A2CYP2D6CYP2C19SLC6A4KMT2A
SCHEMBL8619532 0.83 CYP1A2 (0.57) CYP1A2CYP2D6CYP2C19SLC6A4TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0587670-A4 PCP RECEPTOR LIGANDS AND THE USE THEREOF. OREGON STATE (US) 1995-02-01 EP disclosed
EP-0587670-A1 PCP RECEPTOR LIGANDS AND THE USE THEREOF STATE OF OREGON, acting through OREGON STATE BOARD OF HIGHER EDUCATION, acting for OREGON HEALTH SC. UNIV. AND UNIV. OF OREGON (US) 1994-03-23 EP disclosed