Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.71 |
| ▸ | SLC1A3 | P43003 | 6/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 6/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 6/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | FAP | Q12884 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 4/20 | 0.32 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Valine SCHEMBL2297541 | 0.93 | SLC7A5 (0.75) | SLC7A5SLC1A3SLC1A2SLC1A1TP53 | |
| Valine SCHEMBL7397892 | 0.91 | SLC7A5 (0.71) | SLC7A5SLC1A3SLC1A2SLC1A1TP53 | |
| Valine SCHEMBL27873291 | 0.90 | SLC7A5 (0.79) | SLC7A5SLC1A3SLC1A2SLC1A1TP53 | |
| Valine SCHEMBL247488 | 0.90 | SLC7A5 (0.79) | SLC7A5SLC1A3SLC1A2SLC1A1TP53 | |
| Valine SCHEMBL247489 | 0.90 | SLC7A5 (0.79) | SLC7A5SLC1A3SLC1A2SLC1A1TP53 | |
| Valine SCHEMBL28174037 | 0.88 | SLC7A5 (0.75) | SLC7A5SLC1A3SLC1A2SLC1A1TP53 | |
| Valine SCHEMBL28174038 | 0.88 | SLC7A5 (0.75) | SLC7A5SLC1A3SLC1A2SLC1A1TP53 | |
| Valine SCHEMBL17874440 | 0.88 | SLC7A5 (0.75) | SLC7A5SLC1A3SLC1A2SLC1A1TP53 | |
| Valine SCHEMBL28174036 | 0.88 | SLC7A5 (0.75) | SLC7A5SLC1A3SLC1A2SLC1A1TP53 | |
| Valine SCHEMBL9376703 | 0.88 | SLC7A5 (0.75) | SLC7A5SLC1A3SLC1A2SLC1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641345-A1 | HYPOGLYCEMIC N-SULFONYL-TETRAHYDRO- 1,3]-DIOXEPINO 5,6-B]AZIRINES | PLIVA Handels GmbH (DE) | 1995-03-08 | — | — | EP | disclosed |
| US-5286744-A | Hypoglycemic agents | PLIVA HANDELS GMBH (DE) | 1994-02-15 | — | — | US | disclosed |
| WO-1993004067-A1 | HYPOGLYCEMIC N-SULFONYL-TETRAHYDRO-[1,3]-DIOXEPINO[5,6-B]AZIRINES | PLIVA HANDELS GMBH (DE) | 1993-03-04 | — | — | WO | disclosed |
| US-4235918-A | SALIDIURETICS, TREATMENT OF HYPERTONIC CONDITIONS | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-11-25 | — | — | US | disclosed |
| US-4156735-A | SALIDIURETICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-05-29 | — | — | US | disclosed |
| US-4129656-A | Thiazolidine derivatives, salidiuretic compositions and methods of effecting salidiuresis employing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-12-12 | — | — | US | disclosed |
| US-4118501-A | SALIDIURETIC ACTIVITY | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-10-03 | — | — | US | disclosed |