Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CALCRLCHRM1CHRM2CHRM3F2RMAOAMAOBMAP2K1MAP2K2NTRK1NTRK2NTRK3OPRD1OPRK1OPRM1P2RY12PKLRSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASLC18A2SLC6A2SLC6A3TLR7TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8dacAdacBdacCfolAftsImrcAmrcBmrdApolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmB1rpmB2rpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmHrpmIrpmJrpmJ2rpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsR1rpsR2rpsSrpsTrpsUrpsZykgMykgO
The experimentally established mechanism targets of Valine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.79 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | FAP | Q12884 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | LAP3 | P28838 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 4/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Valine SCHEMBL27873291 | 1.00 | SLC7A5 (0.79) | SLC7A5SLC1A3SLC1A2SLC1A1TP53 | |
| Valine SCHEMBL247489 | 1.00 | SLC7A5 (0.79) | SLC7A5SLC1A3SLC1A2SLC1A1TP53 | |
| Valine SCHEMBL28174037 | 0.97 | SLC7A5 (0.75) | SLC7A5SLC1A3SLC1A2SLC1A1TP53 | |
| Valine SCHEMBL28174036 | 0.97 | SLC7A5 (0.75) | SLC7A5SLC1A3SLC1A2SLC1A1TP53 | |
| Valine SCHEMBL28174038 | 0.97 | SLC7A5 (0.75) | SLC7A5SLC1A3SLC1A2SLC1A1TP53 | |
| Valine SCHEMBL17874440 | 0.92 | SLC7A5 (0.75) | SLC7A5SLC1A3SLC1A2SLC1A1TP53 | |
| Valine SCHEMBL9376703 | 0.92 | SLC7A5 (0.75) | SLC7A5SLC1A3SLC1A2SLC1A1TP53 | |
| Valine SCHEMBL9205010 | 0.90 | SLC7A5 (0.71) | SLC7A5SLC1A3SLC1A2SLC1A1TP53 | |
| Valine SCHEMBL974879 | 0.90 | SLC7A5 (0.79) | SLC7A5SLC1A3SLC1A2SLC1A1TP53 | |
| Valine SCHEMBL8516 | 0.89 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0554422-B1 | USE OF DL-VALIN, ITS ESTERS AND/OR ITS SALTS IN THE TREATMENT OF DANDRUFF | WELLA AG (DE) | 1995-08-30 | — | — | EP | claimed |
| CN-102698808-B | The purposes of a kind of composite catalyst and clean catalytic oxidization cyclohexene synthesizing adipic acid thereof | BEIJING XUYANG CHEMICAL TECHNOLOGY RESEARCH INSTITUTE CO., LTD. (CN) | 2015-07-29 | — | — | CN | disclosed |
| US-8952217-B2 | Process for decreasing verbascose in a plant by expression of a chloroplast-targeted fimD protein | METANOMICS GMBH (DE) | 2015-02-10 | — | — | US | disclosed |
| US-20140325709-A1 | PROCESS FOR THE PRODUCTION OF FINE CHEMICALS | METANOMICS GMBH (DE) | 2014-10-30 | — | — | US | disclosed |
| US-20130198911-A1 | Process for the Production of Fine Chemicals | BASF PLANT SCIENCE GMBH (DE) | 2013-08-01 | — | — | US | disclosed |
| EP-2573188-A2 | Process for the production of fine chemicals | Metanomics GmbH (DE) | 2013-03-27 | — | — | EP | disclosed |
| EP-2434019-A1 | Process for the production of fine chemicals | BASF Plant Science GmbH (DE) | 2012-03-28 | — | — | EP | disclosed |
| US-20120005777-A1 | Process for the Production of Fine Chemicals | BASF PLANT SCIENCE GMBH (DE) | 2012-01-05 | — | — | US | disclosed |
| EP-2368905-A2 | Process for the control of production of fine chemicals | Metanomics GmbH (DE) | 2011-09-28 | — | — | EP | disclosed |
| US-8008545-B2 | Process for the production of fine chemicals | BASF PLANT SCIENCE GMBH (DE) | 2011-08-30 | — | — | US | disclosed |
| US-20060137042-A1 | Process for the production of fine chemicals | BASF PLANT SCIENCE GMBH (DE) | 2006-06-22 | — | — | US | disclosed |
| EP-1654368-A2 | PROCESS FOR THE PRODUCTION OF FINE CHEMICALS | BASF Plant Science GmbH (DE) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005014828-A2 | PROCESS FOR THE PRODUCTION OF FINE CHEMICALS IN PLANTS | BASF PLANT SCIENCE GMBH (DE) | 2005-02-17 | — | — | WO | disclosed |
| CN-1151887-C | L-hydrosulformidate type chiral ionic liquid and its prepn | 华东师范大学 | 2004-06-02 | — | — | CN | disclosed |
| CN-1150994-C | L-sulforamidate type chiral ionic liquid and its prepn | 华东师范大学 | 2004-05-26 | — | — | CN | disclosed |
| EP-1414985-A2 | PROCESS FOR THE FERMENTATIVE PREPARATION OF L-AMINO ACIDS USING CORYNEFORM BACTERIA | Degussa AG (DE) | 2004-05-06 | — | — | EP | disclosed |
| CN-1383920-A | L-sulforamidate type chiral ionic liquid and its prepn | UNIV HUADONG (CN) | 2002-12-11 | — | — | CN | disclosed |
| CN-1383921-A | L-hydrosulformidate type chiral ionic liquid and its prepn | UNIV HUADONG (CN) | 2002-12-11 | — | — | CN | disclosed |
| US-20020168732-A1 | Process for the fermentative preparation of L-amino acids using coryneform bacteria | DEGUSSA AG (DE) | 2002-11-14 | — | — | US | disclosed |
| WO-2002038788-A2 | PROCESS FOR THE FERMENTATIVE PREPARATION OF L-AMINO ACIDS USING CORYNEFORM BACTERIA | DEGUSSA AG (DE) | 2002-05-16 | — | — | WO | disclosed |