Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Podofilox. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.98 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.98 |
| ▸ | TUBB | P07437 | 5/20 | 0.98 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.98 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.98 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.98 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.98 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.98 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.98 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.98 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.98 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.98 |
| ▸ | TUBA1C | Q9BQE3 | 5/20 | 0.98 |
| ▸ | TUBB6 | Q9BUF5 | 5/20 | 0.98 |
| ▸ | TUBB2B | Q9BVA1 | 5/20 | 0.98 |
| ▸ | TUBB1 | Q9H4B7 | 5/20 | 0.98 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.98 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.98 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Podofilox SCHEMBL9205728 | 1.00 | LMNA (0.98) | LMNACYP3A4TUBB4ATUBBTUBA3C | |
| Axl-1717 SCHEMBL1287609 | 1.00 | LMNA (0.98) | LMNACYP3A4TUBB4ATUBBTUBA3C | |
| Podofilox SCHEMBL42243 | 0.99 | LMNA (1.00) | LMNACYP3A4TUBB4ATUBBTUBA3C | |
| Podofilox SCHEMBL20807187 | 0.99 | LMNA (1.00) | LMNACYP3A4TUBB4ATUBBTUBA3C | |
| Podofilox SCHEMBL13663652 | 0.99 | LMNA (1.00) | LMNACYP3A4TUBB4ATUBBTUBA3C | |
| Podofilox SCHEMBL24049951 | 0.99 | LMNA (1.00) | LMNACYP3A4TUBB4ATUBBTUBA3C | |
| Podofilox SCHEMBL10046308 | 0.99 | LMNA (1.00) | LMNACYP3A4TUBB4ATUBBTUBA3C | |
| Podofilox SCHEMBL13661743 | 0.99 | LMNA (1.00) | LMNACYP3A4TUBB4ATUBBTUBA3C | |
| Epipodophyllotoxin SCHEMBL5792464 | 0.99 | LMNA (1.00) | LMNACYP3A4TUBB4ATUBBTUBA3C | |
| Podofilox SCHEMBL10005569 | 0.99 | LMNA (1.00) | LMNACYP3A4TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0664809-A1 | PROCESS FOR PREPARING PURE PODOPHYLLOTOXIN | NYCOMED DANMARK A/S (DK) | 1995-08-02 | — | — | EP | disclosed |
| CN-1099031-A | The method for preparing pure podophyllotoxin | NYCOMED DAK AS (DK) | 1995-02-22 | — | — | CN | disclosed |
| US-5315016-A | Dissolving in solvent which forms azeotrope with solvent present in hydrate, solvate or inclusion compound of podophyllotoxin | NYCOMED DAK A/S (DK) | 1994-05-24 | — | — | US | disclosed |
| WO-1994009008-A1 | PROCESS FOR PREPARING PURE PODOPHYLLOTOXIN | NYCOMED DAK A/S (DK) | 1994-04-28 | — | — | WO | disclosed |