Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRC | P08575 | 2/20 | 0.35 |
| ▸ | BCL2 | P10415 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.32 |
| ▸ | GSTA1 | P08263 | 1/20 | 0.32 |
| ▸ | S100A4 | P26447 | 1/20 | 0.31 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9206731 | 1.00 | PTPRC (0.35) | PTPRCBCL2MCL1ESR1ESR2 | |
| SCHEMBL9205323 | 0.88 | PTPRC (0.34) | PTPRCBCL2MCL1ALOX15CYP2A6 | |
| SCHEMBL9207295 | 0.88 | PTPRC (0.34) | PTPRCBCL2MCL1ALOX15CYP2A6 | |
| SCHEMBL9205329 | 0.88 | PTPRC (0.34) | PTPRCBCL2MCL1ALOX15CYP2A6 | |
| SCHEMBL9207293 | 0.88 | PTPRC (0.34) | PTPRCBCL2MCL1ALOX15CYP2A6 | |
| SCHEMBL9203655 | 0.86 | PTPRC (0.35) | PTPRCBCL2MCL1ESR1ESR2 | |
| SCHEMBL9203647 | 0.86 | PTPRC (0.35) | PTPRCBCL2MCL1ESR1ESR2 | |
| SCHEMBL9207972 | 0.78 | GPR84 (0.42) | PTPRCALOX15MAPK1KDM4ELMNA | |
| SCHEMBL9207977 | 0.78 | GPR84 (0.42) | PTPRCALOX15MAPK1KDM4ELMNA | |
| SCHEMBL9212754 | 0.72 | PTPRC (0.42) | PTPRCALOX15CYP2A6MAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0319073-B1 | Cyclo-octane neuroprotective agents | MERCK SHARP & DOHME (GB) | 1995-08-23 | — | — | EP | disclosed |
| US-4927819-A | ANTICONVULSANT, PREVENTION OF NEURODEGENERATIVE DISORDERS | MERCK SHARP & DOHME LIMITED (GB) | 1990-05-22 | — | — | US | disclosed |
| EP-0319073-A2 | Cyclo-octane neuroprotective agents | MERCK SHARP & DOHME LTD. (GB) | 1989-06-07 | — | — | EP | disclosed |