Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.50 |
| ▸ | MPO | P05164 | 1/20 | 0.50 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.50 |
| ▸ | CTSV | O60911 | 1/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30309524 | 1.00 | MAPT (0.57) | MAPTKMT2AALDH1A1CYP3A4ALOX15 | |
| SCHEMBL18113450 | 0.88 | KMT2A (0.60) | MAPTKMT2AALDH1A1CYP3A4ALOX15 | |
| SCHEMBL4211532 | 0.88 | KMT2A (0.72) | MAPTKMT2AALDH1A1TP53HTT | |
| SCHEMBL27711285 | 0.87 | SMN1; SMN2 (0.50) | MAPTKMT2AALDH1A1TP53HTT | |
| SCHEMBL9507979 | 0.85 | HCAR3 (0.58) | MAPTKMT2AALDH1A1CYP3A4ALOX15 | |
| SCHEMBL3694733 | 0.83 | MAPT (0.77) | MAPTKMT2AALDH1A1CYP3A4ALOX15 | |
| SCHEMBL6618197 | 0.82 | KMT2A (0.60) | MAPTKMT2AALDH1A1CYP3A4ALOX15 | |
| SCHEMBL12703765 | 0.82 | KMT2A (0.61) | MAPTKMT2AALDH1A1CYP3A4ALOX15 | |
| SCHEMBL31520812 | 0.81 | KMT2A (0.55) | MAPTKMT2AALDH1A1CYP3A4ALOX15 | |
| SCHEMBL31520640 | 0.81 | CDK2 (0.55) | MAPTKMT2AALDH1A1CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0459561-B1 | Dioxo-tetrahydroquinoline derivatives | MERCK SHARP & DOHME (GB) | 1995-09-20 | — | — | EP | disclosed |
| US-5268378-A | Oxo group in 2 and 4 position | MERCK SHARP & DOHME, LIMITED (GB) | 1993-12-07 | — | — | US | disclosed |
| EP-0459561-A2 | Dioxo-tetrahydroquinoline derivatives | MERCK SHARP & DOHME LTD. (GB) | 1991-12-04 | — | — | EP | disclosed |