Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.58 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 3/20 | 0.40 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.37 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20594659 | 0.87 | MAPK14 (0.72) | MAPK14PDK2PDK4PGRATAD2 | |
| SCHEMBL17275839 | 0.81 | MAPK14 (0.55) | MAPK14PDK2PDK4PGRATAD2 | |
| SCHEMBL29906734 | 0.80 | MAPK14 (0.57) | MAPK14PDK2PDK4PGRATAD2 | |
| SCHEMBL4793061 | 0.79 | MAPK14 (0.56) | MAPK14PDK2PDK4PGRATAD2 | |
| SCHEMBL16323842 | 0.78 | ALDH1A1 (0.60) | MAPK14PDK2PDK4PGRKDM4E | |
| SCHEMBL18736026 | 0.78 | MAPK14 (0.49) | MAPK14PDK2PDK4PGRATAD2 | |
| SCHEMBL29825095 | 0.76 | MAPK14 (0.53) | MAPK14PDK2PDK4PGRKDM4E | |
| SCHEMBL16321516 | 0.76 | MAPK14 (0.53) | MAPK14PDK2PDK4PGRKDM4E | |
| Hydrochloric Acid SCHEMBL9202414 | 0.76 | RARB (0.54) | MAPK14PRSS1PRSS2PRSS3PLAU | |
| SCHEMBL17275732 | 0.76 | MAPK14 (0.50) | MAPK14PDK2PDK4PGRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497852-B1 | BICYCLO-IMIDAZOLES, PROCESS FOR PRODUCING THEM AND DRUGS CONTAINING THEM | BOEHRINGER MANNHEIM GMBH (DE) | 1995-12-20 | — | — | EP | disclosed |
| EP-0497852-A1 | BICYCLO-IMIDAZOLES, PROCESS FOR PRODUCING THEM AND DRUGS CONTAINING THEM. | BOEHRINGER MANNHEIM GMBH (DE) | 1992-08-12 | — | — | EP | disclosed |
| WO-1991006545-A1 | BICYCLO-IMIDAZOLES, PROCESS FOR PRODUCING THEM AND DRUGS CONTAINING THEM | BOEHRINGER MANNHEIM GMBH (DE) | 1991-05-16 | — | — | WO | disclosed |